POLYMERIZATION OF LIPOSOMES COMPOSED OF DIENE-CONTAINING LIPIDS BY RADICAL INITIATORS. II. POLYMERIZATION OF MONODIENE-TYPE LIPIDS AS LIPOSOMES.

Hiroyuki Ohno, Shinji Takeoka, Hidetaka Iwai, Eishun Tsuchida

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    1-Palmitoyl-2(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (POPC), a polymerizable lipid that contains one diene group in only a 2-acyl chain, was polymerized as liposome in an aqueous medium. Polymerization was initiated by water-insoluble azobisisobutyronitrile (AIBN), or water-soluble azobis(2-amidinopropane) dihydrochloride (AAPD). AIBN was mixed with monomeric lipids, and the mixture was dispersed in an aqueous medium by sonication to prepare AIBN-containing monomeric lipid liposomes. On the other hand, AAPD was simply added to the liposome suspension. The POPC liposomes were easily polymerized by the addition of AAPD, a water-soluble radical initiator, but few were polymerized by AIBN. The results suggested that the diene group in the 2 acyl chain was in an aqueous phase and, therefore, easily polymerized by a water-soluble radical initiator.

    Original languageEnglish
    Pages (from-to)2737-2746
    Number of pages10
    JournalJournal of Polymer Science, Part A: Polymer Chemistry
    Volume25
    Issue number10
    Publication statusPublished - 1987 Oct

    Fingerprint

    Liposomes
    Lipids
    Polymerization
    Water
    Sonication
    Phosphorylcholine
    Suspensions
    azobis(isobutyronitrile)

    ASJC Scopus subject areas

    • Materials Chemistry
    • Polymers and Plastics

    Cite this

    POLYMERIZATION OF LIPOSOMES COMPOSED OF DIENE-CONTAINING LIPIDS BY RADICAL INITIATORS. II. POLYMERIZATION OF MONODIENE-TYPE LIPIDS AS LIPOSOMES. / Ohno, Hiroyuki; Takeoka, Shinji; Iwai, Hidetaka; Tsuchida, Eishun.

    In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 25, No. 10, 10.1987, p. 2737-2746.

    Research output: Contribution to journalArticle

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    abstract = "1-Palmitoyl-2(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (POPC), a polymerizable lipid that contains one diene group in only a 2-acyl chain, was polymerized as liposome in an aqueous medium. Polymerization was initiated by water-insoluble azobisisobutyronitrile (AIBN), or water-soluble azobis(2-amidinopropane) dihydrochloride (AAPD). AIBN was mixed with monomeric lipids, and the mixture was dispersed in an aqueous medium by sonication to prepare AIBN-containing monomeric lipid liposomes. On the other hand, AAPD was simply added to the liposome suspension. The POPC liposomes were easily polymerized by the addition of AAPD, a water-soluble radical initiator, but few were polymerized by AIBN. The results suggested that the diene group in the 2 acyl chain was in an aqueous phase and, therefore, easily polymerized by a water-soluble radical initiator.",
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    AB - 1-Palmitoyl-2(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (POPC), a polymerizable lipid that contains one diene group in only a 2-acyl chain, was polymerized as liposome in an aqueous medium. Polymerization was initiated by water-insoluble azobisisobutyronitrile (AIBN), or water-soluble azobis(2-amidinopropane) dihydrochloride (AAPD). AIBN was mixed with monomeric lipids, and the mixture was dispersed in an aqueous medium by sonication to prepare AIBN-containing monomeric lipid liposomes. On the other hand, AAPD was simply added to the liposome suspension. The POPC liposomes were easily polymerized by the addition of AAPD, a water-soluble radical initiator, but few were polymerized by AIBN. The results suggested that the diene group in the 2 acyl chain was in an aqueous phase and, therefore, easily polymerized by a water-soluble radical initiator.

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