Polymerization of liposomes evaluated from molecular weight distribution of diene-type phospholipid polymers

Shinji Takeoka, Noboru Kimura, Hiroyuki Ohno, Eishun Tsuchida

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    1,2-Bis(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) or 1-palmitoyl-2-(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (POPC) was dispersed in water by sonication to form liposomes. DODPC liposomes were polymerized by UV-irradiation or with radical initiator such as azobis(2-amidinopropane)dihydrochloride (AAPD) at 60°C and methanolyzed to obtain THF-soluble polymers. The molecular weight distribution obtained from a gel permeation chromatography reveals that the UV-irradiation provides low-molecular-weight products and a small amount of polymers, while free radical polymerization gives polymers having relatively high-molecular-weight. The molecular weight of the phospholipid polymers is also influenced by the assembling state. The constrained lipid packing of small unilamellar POPC liposomes provides relatively low-molecular-weight polymers in comparison with those of larger liposomes. In addition, POPC liposomes polymerized at the temperature above gel-to-liquid crystalline phase transition temperature (Tc) show the higher molecular weight of polymers than those polymerized below the Tc.

    Original languageEnglish
    Pages (from-to)867-874
    Number of pages8
    JournalPolymer Journal
    Volume22
    Issue number10
    Publication statusPublished - 1990

    Fingerprint

    Liposomes
    Phospholipids
    Molecular weight distribution
    Polymers
    Phosphorylcholine
    Polymerization
    Molecular weight
    Irradiation
    Sonication
    Gel permeation chromatography
    Free radical polymerization
    Lipids
    Superconducting transition temperature
    Gels
    Phase transitions
    Crystalline materials
    Water
    Liquids

    ASJC Scopus subject areas

    • Materials Chemistry
    • Polymers and Plastics

    Cite this

    Polymerization of liposomes evaluated from molecular weight distribution of diene-type phospholipid polymers. / Takeoka, Shinji; Kimura, Noboru; Ohno, Hiroyuki; Tsuchida, Eishun.

    In: Polymer Journal, Vol. 22, No. 10, 1990, p. 867-874.

    Research output: Contribution to journalArticle

    Takeoka, Shinji ; Kimura, Noboru ; Ohno, Hiroyuki ; Tsuchida, Eishun. / Polymerization of liposomes evaluated from molecular weight distribution of diene-type phospholipid polymers. In: Polymer Journal. 1990 ; Vol. 22, No. 10. pp. 867-874.
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