Abstract
Amino acids are utilized as medical raw materials and food additives. It is well-known that most of the amino acids show polymorphism. Differences in the crystal structures affect the physical and chemical properties. Therefore, an effective method for polymorph control is required in the crystallization process. Polymorph control of L-arginine hydrochloride (L-ArgHCl) on antisolvent crystallization was achieved by ultrasonic irradiation. L-ArgHCl exhibits polymorphism and crystallizes into three distinct crystal forms. Without irradiation, the metastable form was selectively crystallized. In contrast, the unstable form was selectively crystallized by irradiation. Irradiation after the addition of an antisolvent led to a shorter induction time.
| Original language | English |
|---|---|
| Pages (from-to) | 1318-1322 |
| Number of pages | 5 |
| Journal | Chemical Engineering and Technology |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2017 Jul 1 |
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Keywords
- Amino acids
- Nucleation
- Polymorphism
- Sonocrystallization
- Ultrasound
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
- Industrial and Manufacturing Engineering
Cite this
Polymorph Control of L-ArgHCl on Antisolvent Crystallization by Ultrasonic Irradiation. / Ike, Yuki; Hirasawa, Izumi.
In: Chemical Engineering and Technology, Vol. 40, No. 7, 01.07.2017, p. 1318-1322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymorph Control of L-ArgHCl on Antisolvent Crystallization by Ultrasonic Irradiation
AU - Ike, Yuki
AU - Hirasawa, Izumi
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Amino acids are utilized as medical raw materials and food additives. It is well-known that most of the amino acids show polymorphism. Differences in the crystal structures affect the physical and chemical properties. Therefore, an effective method for polymorph control is required in the crystallization process. Polymorph control of L-arginine hydrochloride (L-ArgHCl) on antisolvent crystallization was achieved by ultrasonic irradiation. L-ArgHCl exhibits polymorphism and crystallizes into three distinct crystal forms. Without irradiation, the metastable form was selectively crystallized. In contrast, the unstable form was selectively crystallized by irradiation. Irradiation after the addition of an antisolvent led to a shorter induction time.
AB - Amino acids are utilized as medical raw materials and food additives. It is well-known that most of the amino acids show polymorphism. Differences in the crystal structures affect the physical and chemical properties. Therefore, an effective method for polymorph control is required in the crystallization process. Polymorph control of L-arginine hydrochloride (L-ArgHCl) on antisolvent crystallization was achieved by ultrasonic irradiation. L-ArgHCl exhibits polymorphism and crystallizes into three distinct crystal forms. Without irradiation, the metastable form was selectively crystallized. In contrast, the unstable form was selectively crystallized by irradiation. Irradiation after the addition of an antisolvent led to a shorter induction time.
KW - Amino acids
KW - Nucleation
KW - Polymorphism
KW - Sonocrystallization
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85020019376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020019376&partnerID=8YFLogxK
U2 - 10.1002/ceat.201600678
DO - 10.1002/ceat.201600678
M3 - Article
VL - 40
SP - 1318
EP - 1322
JO - Chemical Engineering and Technology
JF - Chemical Engineering and Technology
SN - 0930-7516
IS - 7
ER -