Polymorph Control of L-ArgHCl on Antisolvent Crystallization by Ultrasonic Irradiation

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Amino acids are utilized as medical raw materials and food additives. It is well-known that most of the amino acids show polymorphism. Differences in the crystal structures affect the physical and chemical properties. Therefore, an effective method for polymorph control is required in the crystallization process. Polymorph control of L-arginine hydrochloride (L-ArgHCl) on antisolvent crystallization was achieved by ultrasonic irradiation. L-ArgHCl exhibits polymorphism and crystallizes into three distinct crystal forms. Without irradiation, the metastable form was selectively crystallized. In contrast, the unstable form was selectively crystallized by irradiation. Irradiation after the addition of an antisolvent led to a shorter induction time.

    Original languageEnglish
    Pages (from-to)1318-1322
    Number of pages5
    JournalChemical Engineering and Technology
    Volume40
    Issue number7
    DOIs
    Publication statusPublished - 2017 Jul 1

    Fingerprint

    Arginine
    Crystallization
    Polymorphism
    Ultrasonics
    Irradiation
    Amino acids
    Food additives
    Amino Acids
    Chemical properties
    Raw materials
    Physical properties
    Crystal structure
    Crystals

    Keywords

    • Amino acids
    • Nucleation
    • Polymorphism
    • Sonocrystallization
    • Ultrasound

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)
    • Industrial and Manufacturing Engineering

    Cite this

    Polymorph Control of L-ArgHCl on Antisolvent Crystallization by Ultrasonic Irradiation. / Ike, Yuki; Hirasawa, Izumi.

    In: Chemical Engineering and Technology, Vol. 40, No. 7, 01.07.2017, p. 1318-1322.

    Research output: Contribution to journalArticle

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