Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering

Akira Yoshikawa; Takayuki Yanagida; Kei Kamada; Yuui Yokota; Jan Pejchal; Akihiro Yamaji; Yoshiyuki Usuki; Seiichi Yamamoto; Masayasu Miyake; Kazuaki Kumagai; Katsuhisa Sasaki; T. R. Dos Santos; Mamoru Baba; Masatoshi Ito; Motohiro Takeda; Noriaki Ohuchi; Martin Nikl

doi:10.1016/j.optmat.2010.05.002

Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering

Akira Yoshikawa^*, Takayuki Yanagida, Kei Kamada, Yuui Yokota, Jan Pejchal, Akihiro Yamaji, Yoshiyuki Usuki, Seiichi Yamamoto, Masayasu Miyake, Kazuaki Kumagai, Katsuhisa Sasaki, T. R. Dos Santos, Mamoru Baba, Masatoshi Ito, Motohiro Takeda, Noriaki Ohuchi, Martin Nikl

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The breast cancer is one of the most frequent cause of death among female cancer patients. However, when discovered at the early stage, the probability of recovery is very high. Therefore, the development of positron emission mammography (PEM) to detect the breast cancer at the early stage with high efficiency is demanding. As the diameter of the scanner part is small, a scintillator with faster response is required. As the recently developed Pr:LuAG has almost twice as short scintillation decay time than that of Ce:LSO, the Pr:LuAG scintillator was employed in our recently developed PEM system. One camera unit consisted of 20 × 64 scintillator pixels optically coupled with three H8500-03 multi anode photomultipliers. The Pr:LuAG pixel size is 2.1 × 2.1 × 15 mm³ and the BaSO₄ was used as a reflector. Four planar cameras are placed at both sides. Therefore, eight cameras were installed at both sides of the instrument. The spatial resolution was evaluated to be 1.1 mm using the ²²Na point source. Fluorodeoxyglucose with ¹⁸F hotspot image was also detected using the breast phantom.

Original language	English
Pages (from-to)	1294-1297
Number of pages	4
Journal	Optical Materials
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/j.optmat.2010.05.002
Publication status	Published - 2010 Aug
Externally published	Yes

Keywords

Gamma camera
PEM
PET
Pr:LuAG
Scintillator

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Spectroscopy
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.optmat.2010.05.002

Cite this

Yoshikawa, A., Yanagida, T., Kamada, K., Yokota, Y., Pejchal, J., Yamaji, A., Usuki, Y., Yamamoto, S., Miyake, M., Kumagai, K., Sasaki, K., Dos Santos, T. R., Baba, M., Ito, M., Takeda, M., Ohuchi, N., & Nikl, M. (2010). Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering. Optical Materials, 32(10), 1294-1297. https://doi.org/10.1016/j.optmat.2010.05.002

Yoshikawa, A, Yanagida, T, Kamada, K, Yokota, Y, Pejchal, J, Yamaji, A, Usuki, Y, Yamamoto, S, Miyake, M, Kumagai, K, Sasaki, K, Dos Santos, TR, Baba, M, Ito, M, Takeda, M, Ohuchi, N & Nikl, M 2010, 'Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering', Optical Materials, vol. 32, no. 10, pp. 1294-1297. https://doi.org/10.1016/j.optmat.2010.05.002

@article{bbcc3b8c584c4e4b9d82f536f00b030d,

title = "Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering",

abstract = "The breast cancer is one of the most frequent cause of death among female cancer patients. However, when discovered at the early stage, the probability of recovery is very high. Therefore, the development of positron emission mammography (PEM) to detect the breast cancer at the early stage with high efficiency is demanding. As the diameter of the scanner part is small, a scintillator with faster response is required. As the recently developed Pr:LuAG has almost twice as short scintillation decay time than that of Ce:LSO, the Pr:LuAG scintillator was employed in our recently developed PEM system. One camera unit consisted of 20 × 64 scintillator pixels optically coupled with three H8500-03 multi anode photomultipliers. The Pr:LuAG pixel size is 2.1 × 2.1 × 15 mm3 and the BaSO4 was used as a reflector. Four planar cameras are placed at both sides. Therefore, eight cameras were installed at both sides of the instrument. The spatial resolution was evaluated to be 1.1 mm using the 22Na point source. Fluorodeoxyglucose with 18F hotspot image was also detected using the breast phantom.",

keywords = "Gamma camera, PEM, PET, Pr:LuAG, Scintillator",

author = "Akira Yoshikawa and Takayuki Yanagida and Kei Kamada and Yuui Yokota and Jan Pejchal and Akihiro Yamaji and Yoshiyuki Usuki and Seiichi Yamamoto and Masayasu Miyake and Kazuaki Kumagai and Katsuhisa Sasaki and {Dos Santos}, {T. R.} and Mamoru Baba and Masatoshi Ito and Motohiro Takeda and Noriaki Ohuchi and Martin Nikl",

note = "Funding Information: This work was partially supported by Japan Science and Technology Agency, Regional Research and Development Resources Utilization Program. Partial support of Ministry of Education, Culture, Sports, Science and Technology of Japanese Government, Grant-in-Aid for Young Scientists (A), 19686001 (AY) and (B), 15686001 (TY), JSPS P08055, joint project between JSPS & ASCR, and Czech GAAV project M100100910 are also appreciated.",

year = "2010",

month = aug,

doi = "10.1016/j.optmat.2010.05.002",

language = "English",

volume = "32",

pages = "1294--1297",

journal = "Optical Materials",

issn = "0925-3467",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering

AU - Yoshikawa, Akira

AU - Yanagida, Takayuki

AU - Kamada, Kei

AU - Yokota, Yuui

AU - Pejchal, Jan

AU - Yamaji, Akihiro

AU - Usuki, Yoshiyuki

AU - Yamamoto, Seiichi

AU - Miyake, Masayasu

AU - Kumagai, Kazuaki

AU - Sasaki, Katsuhisa

AU - Dos Santos, T. R.

AU - Baba, Mamoru

AU - Ito, Masatoshi

AU - Takeda, Motohiro

AU - Ohuchi, Noriaki

AU - Nikl, Martin

N1 - Funding Information: This work was partially supported by Japan Science and Technology Agency, Regional Research and Development Resources Utilization Program. Partial support of Ministry of Education, Culture, Sports, Science and Technology of Japanese Government, Grant-in-Aid for Young Scientists (A), 19686001 (AY) and (B), 15686001 (TY), JSPS P08055, joint project between JSPS & ASCR, and Czech GAAV project M100100910 are also appreciated.

PY - 2010/8

Y1 - 2010/8

N2 - The breast cancer is one of the most frequent cause of death among female cancer patients. However, when discovered at the early stage, the probability of recovery is very high. Therefore, the development of positron emission mammography (PEM) to detect the breast cancer at the early stage with high efficiency is demanding. As the diameter of the scanner part is small, a scintillator with faster response is required. As the recently developed Pr:LuAG has almost twice as short scintillation decay time than that of Ce:LSO, the Pr:LuAG scintillator was employed in our recently developed PEM system. One camera unit consisted of 20 × 64 scintillator pixels optically coupled with three H8500-03 multi anode photomultipliers. The Pr:LuAG pixel size is 2.1 × 2.1 × 15 mm3 and the BaSO4 was used as a reflector. Four planar cameras are placed at both sides. Therefore, eight cameras were installed at both sides of the instrument. The spatial resolution was evaluated to be 1.1 mm using the 22Na point source. Fluorodeoxyglucose with 18F hotspot image was also detected using the breast phantom.

AB - The breast cancer is one of the most frequent cause of death among female cancer patients. However, when discovered at the early stage, the probability of recovery is very high. Therefore, the development of positron emission mammography (PEM) to detect the breast cancer at the early stage with high efficiency is demanding. As the diameter of the scanner part is small, a scintillator with faster response is required. As the recently developed Pr:LuAG has almost twice as short scintillation decay time than that of Ce:LSO, the Pr:LuAG scintillator was employed in our recently developed PEM system. One camera unit consisted of 20 × 64 scintillator pixels optically coupled with three H8500-03 multi anode photomultipliers. The Pr:LuAG pixel size is 2.1 × 2.1 × 15 mm3 and the BaSO4 was used as a reflector. Four planar cameras are placed at both sides. Therefore, eight cameras were installed at both sides of the instrument. The spatial resolution was evaluated to be 1.1 mm using the 22Na point source. Fluorodeoxyglucose with 18F hotspot image was also detected using the breast phantom.

KW - Gamma camera

KW - PEM

KW - PET

KW - Pr:LuAG

KW - Scintillator

UR - http://www.scopus.com/inward/record.url?scp=77955768702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955768702&partnerID=8YFLogxK

U2 - 10.1016/j.optmat.2010.05.002

DO - 10.1016/j.optmat.2010.05.002

M3 - Article

AN - SCOPUS:77955768702

SN - 0925-3467

VL - 32

SP - 1294

EP - 1297

JO - Optical Materials

JF - Optical Materials

IS - 10

ER -

Positron emission mammography using Pr:LuAG scintillator - Fusion of optical material study and systems engineering

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this