Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors

Mikhail F. Chernov, Takakazu Kawamata, Kosaku Amano, Yuko Ono, Takashi Suzuki, Ryoichi Nakamura, Yoshihiro Muragaki, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Kintomo Takakura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The objective of the present study was investigation of the possible role of proton magnetic resonance spectroscopy (1H-MRS) for differential diagnosis of suprasellar tumors. Forty patients (23 men and 17 women; median age, 45 years) with suprasellar, hypothalamic, and third ventricle neoplasms underwent long-echo (TR: 2000 ms, TE: 136 ms, 128-256 acquisitions) single-voxel 1H-MRS before surgical treatment. The volume of the voxel was either 3.4 cc or 8 cc. Spectroscopic data were analyzed by calculation of the various metabolite ratios as well as by determination of the type of the pathological 1H-MR spectra. There were 19 pituitary adenomas, 7 gliomas, 5 craniopharyngiomas, 3 chordomas, meningioma, hemangiopericytoma, malignant lymphoma, germinoma, Rathke cleft cyst, and hypothalamic hamartoma (one of each). Six tumors were recurrent after initial surgical resection with or without irradiation. Comparison of the individual metabolite ratios revealed only few subtle differences among neoplasms. In the same time, pattern analysis with determination of the type of the pathological 1H-MR spectra disclosed certain specific characteristics, which seemingly can be used for tumor typing. Meanwhile, metabolic imaging was less effective for characterization of recurrent neoplasms. In conclusion, in cases of initially diagnosed suprasellar tumors with involvement of the hypothalamus and extension into the third ventricle pattern analysis of the single-voxel 1H-MRS can provide valuable information, which, in addition to structural MRI, can be effectively used for diagnostic purposes.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalJournal of Neuro-Oncology
Volume91
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Differential Diagnosis
Neoplasms
Third Ventricle
Central Nervous System Cysts
Germinoma
Hemangiopericytoma
Chordoma
Craniopharyngioma
Pituitary Neoplasms
Meningioma
Proton Magnetic Resonance Spectroscopy
Glioma
Hypothalamus
Lymphoma

Keywords

  • Chordoma
  • Craniopharyngioma
  • Differential diagnosis
  • Glioma
  • Pituitary adenoma
  • Protonmagnetic resonance spectroscopy
  • Suprasellar tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Chernov, M. F., Kawamata, T., Amano, K., Ono, Y., Suzuki, T., Nakamura, R., ... Takakura, K. (2009). Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors. Journal of Neuro-Oncology, 91(2), 191-198. https://doi.org/10.1007/s11060-008-9698-y

Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors. / Chernov, Mikhail F.; Kawamata, Takakazu; Amano, Kosaku; Ono, Yuko; Suzuki, Takashi; Nakamura, Ryoichi; Muragaki, Yoshihiro; Iseki, Hiroshi; Kubo, Osami; Hori, Tomokatsu; Takakura, Kintomo.

In: Journal of Neuro-Oncology, Vol. 91, No. 2, 2009, p. 191-198.

Research output: Contribution to journalArticle

Chernov, MF, Kawamata, T, Amano, K, Ono, Y, Suzuki, T, Nakamura, R, Muragaki, Y, Iseki, H, Kubo, O, Hori, T & Takakura, K 2009, 'Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors', Journal of Neuro-Oncology, vol. 91, no. 2, pp. 191-198. https://doi.org/10.1007/s11060-008-9698-y
Chernov, Mikhail F. ; Kawamata, Takakazu ; Amano, Kosaku ; Ono, Yuko ; Suzuki, Takashi ; Nakamura, Ryoichi ; Muragaki, Yoshihiro ; Iseki, Hiroshi ; Kubo, Osami ; Hori, Tomokatsu ; Takakura, Kintomo. / Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors. In: Journal of Neuro-Oncology. 2009 ; Vol. 91, No. 2. pp. 191-198.
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