Possible roles for the hominoid-specific dscr4 gene in human cells

Morteza M. Saber, Marziyeh Karimiavargani, Takanori Uzawa, Nilmini Hettiarachchi, Michiaki Hamada, Yoshihiro Ito, Naruya Saitou

Research output: Contribution to journalComment/debatepeer-review

Abstract

Legends to Figures 4 and 5 (p. 7) should be exchanged. Below are the correct legends to Figure 4 and Figure 5. Fig. 4. Interconnection of DSCR4 overexpression-mediated perturbed path-ways. KEGG analysis of DSCR4 overexpression-mediated DEGs shows enrich-ment for the tightly interconnected pathways of the coagulation cascade and the complement cascade (highlighted in red) and further confirm the connection of these cascades with cell adhesion, migration and proliferation (red circle). Fig. 5. Expression profile of DSCR4 across human cell lines and tissues. Accord-ing to Roadmap Epigenomics Project data, DSCR4 and DSCR8, which share a bidirectional promoter, are highly expressed only in K562 cells, a type of leukemia cell. Analysis of transcriptome data provided by Prescott et al. (2015) showed that DSCR4 and DSCR8 also display high expression in human and chimpanzee neural crest cells, which are critical migratory cells involved in facial morphogenesis in the embryo. (1) Data from Prescott et al. (2015). (2) Samples also include esophagus, lung, spleen and fetal large intestine. (3) Samples also include brain germinal matrix, hippocampus, fetal small intestine, stomach, left ventricle, small intestine, sigmoid colon, HEPG2 cells and HMEC cells. The PDF file for DOI: https://doi.org/10.1266/ggs.20-00012 has been replaced with the corrected version as of June 17, 2021.

Original languageEnglish
Pages (from-to)105
Number of pages1
JournalGenes and Genetic Systems
Volume96
Issue number2
DOIs
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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