Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro

Yoshiki Mukudai, Seiji Kondo, Tomoyuki Koyama, Chunnan Li, Seika Banka, Akiko Kogure, Kazunaga Yazawa, Satoru Shintani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Osteoporosis (OP) is one of the most serious diseases in the modern world, and OP patients frequently suffer from fragility fractures in the hip, spine and wrist, resulting in a limited quality of life. Although bisphosphonates (BPs) are the most effective class of anti-bone-resorptive drugs currently available and the most commonly prescribed for the clinical treatment of OP, they are known to cause serious side effects such as bisphosphonate-related osteonecrosis of the jaw. Novel therapeutic materials that can replace the use of BPs have therefore been developed.Methods: We commenced an institutional collaborative project in which candidates of herbal extracts were selected from more than 400 bioactive herbal products for their potential therapeutic effects not only in OP, but also in oral and skeletal diseases. In the present study, we report on 3 Chinese medical herbal extracts from the root barks of Melia azedarach, Corydalis turtschaninovii, and Cynanchum atratum.Results: All of these extracts inhibited osteoclast proliferation and induced apoptosis by up-regulation of caspase activity and increase of mitochondrial pro-apoptotic proteins expression. Furthermore, the extracts enhanced differentiation, but did not affect proliferation of both osteoblasts and chondrocytes. The osteo-inducible effect was also observed in cultured primary bone marrow cells.Conclusions: Although these extracts have been utilized in traditional Chinese medicine for hundreds of years, there are no reports to our knowledge, on their therapeutic effects in OP. In this study, we elucidate the potency of these herbal extracts as novel candidates for OP therapy.

Original languageEnglish
Article number29
JournalBMC Complementary and Alternative Medicine
Volume14
DOIs
Publication statusPublished - 2014 Jan 17
Externally publishedYes

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Osteoclasts
Chondrocytes
Osteoblasts
Osteoporosis
Diphosphonates
Therapeutic Uses
Melia azedarach
Mouth Diseases
Corydalis
Bisphosphonate-Associated Osteonecrosis of the Jaw
Apoptosis Regulatory Proteins
Mitochondrial Proteins
Chinese Traditional Medicine
Hip Fractures
Caspases
Wrist
Bone Marrow Cells
In Vitro Techniques
Spine
Up-Regulation

Keywords

  • Herbal extract
  • Osteoblast
  • Osteoclast
  • Osteoporosis
  • Shondrocyte
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro. / Mukudai, Yoshiki; Kondo, Seiji; Koyama, Tomoyuki; Li, Chunnan; Banka, Seika; Kogure, Akiko; Yazawa, Kazunaga; Shintani, Satoru.

In: BMC Complementary and Alternative Medicine, Vol. 14, 29, 17.01.2014.

Research output: Contribution to journalArticle

Mukudai, Yoshiki ; Kondo, Seiji ; Koyama, Tomoyuki ; Li, Chunnan ; Banka, Seika ; Kogure, Akiko ; Yazawa, Kazunaga ; Shintani, Satoru. / Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro. In: BMC Complementary and Alternative Medicine. 2014 ; Vol. 14.
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