Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography

Kiichi Ishiwata, Masaki Mizuno, Yuichi Kimura, Kazunori Kawamura, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kenji Ishii

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.

Original languageEnglish
Pages (from-to)949-956
Number of pages8
JournalNuclear Medicine and Biology
Volume31
Issue number7
DOIs
Publication statusPublished - 2004 Oct 1

    Fingerprint

Keywords

  • Adenosine A receptor
  • Human
  • Muscle
  • Positron emission tomography
  • [C]TMSX

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this