Practical approach for hydroheteroarylation of alkynes using bench-stable catalyst

Kyalo Stephen Kanyiva, Yoshiaki Nakao, Tamejiro Hiyama

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A simple and convenient method for hydroheteroarylation of alkynes using air- stable catalyst precursors is described. The addition of a solution of AlMe3 in hexane to Ni(acac)2 and tri(cyclopentyl)phosphonium tetrafluoroborate ([Cyp3PH\BF4) rapidly generates an active Ni(0)/Cyp3P catalyst for cis-hydroheteroarylation of alkynes under mild conditions. The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo- and regioselectivities.

Original languageEnglish
Pages (from-to)677-680
Number of pages4
JournalHeterocycles
Volume72
DOIs
Publication statusPublished - 2007 Apr 13
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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