Practical approach for hydroheteroarylation of alkynes using bench-stable catalyst

Kyalo Stephen Kanyiva; Yoshiaki Nakao; Tamejiro Hiyama

doi:10.3987/com-06-s(k)29

Practical approach for hydroheteroarylation of alkynes using bench-stable catalyst

Kyalo Stephen Kanyiva^*, Yoshiaki Nakao, Tamejiro Hiyama

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A simple and convenient method for hydroheteroarylation of alkynes using air- stable catalyst precursors is described. The addition of a solution of AlMe₃ in hexane to Ni(acac)₂ and tri(cyclopentyl)phosphonium tetrafluoroborate ([Cyp₃PH\BF₄) rapidly generates an active Ni(0)/Cyp₃P catalyst for cis-hydroheteroarylation of alkynes under mild conditions. The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo- and regioselectivities.

Original language	English
Pages (from-to)	677-680
Number of pages	4
Journal	Heterocycles
Volume	72
DOIs	https://doi.org/10.3987/com-06-s(k)29
Publication status	Published - 2007 Apr 13
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "A simple and convenient method for hydroheteroarylation of alkynes using air- stable catalyst precursors is described. The addition of a solution of AlMe3 in hexane to Ni(acac)2 and tri(cyclopentyl)phosphonium tetrafluoroborate ([Cyp3PH\BF4) rapidly generates an active Ni(0)/Cyp3P catalyst for cis-hydroheteroarylation of alkynes under mild conditions. The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo- and regioselectivities.",

author = "Kanyiva, {Kyalo Stephen} and Yoshiaki Nakao and Tamejiro Hiyama",

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AU - Kanyiva, Kyalo Stephen

AU - Nakao, Yoshiaki

AU - Hiyama, Tamejiro

PY - 2007/4/13

Y1 - 2007/4/13

N2 - A simple and convenient method for hydroheteroarylation of alkynes using air- stable catalyst precursors is described. The addition of a solution of AlMe3 in hexane to Ni(acac)2 and tri(cyclopentyl)phosphonium tetrafluoroborate ([Cyp3PH\BF4) rapidly generates an active Ni(0)/Cyp3P catalyst for cis-hydroheteroarylation of alkynes under mild conditions. The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo- and regioselectivities.

AB - A simple and convenient method for hydroheteroarylation of alkynes using air- stable catalyst precursors is described. The addition of a solution of AlMe3 in hexane to Ni(acac)2 and tri(cyclopentyl)phosphonium tetrafluoroborate ([Cyp3PH\BF4) rapidly generates an active Ni(0)/Cyp3P catalyst for cis-hydroheteroarylation of alkynes under mild conditions. The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo- and regioselectivities.

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AN - SCOPUS:34547830422

SN - 0385-5414

VL - 72

SP - 677

EP - 680

JO - Heterocycles

JF - Heterocycles

ER -

Practical approach for hydroheteroarylation of alkynes using bench-stable catalyst

Abstract

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