Practically perfect asymmetric autocatalysis with (2-alkynyl-5- pyrimidyl)alkanols

Takanori Shibata, S. Yonekubo, K. Soai

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Extremely high enantioselectivity (> 99.5% ee) and chemical yield (> 99%) are achieved in an asymmetric autocatalytic reaction. A (5- pyrimidyl)alkanol with a tert-butylethynyl group at its 2-position (1) is a very efficient asymmetric autocatalyst in the enantioselective alkylation in Equation (1).

Original languageEnglish
Pages (from-to)659-661
Number of pages3
JournalAngewandte Chemie - International Edition
Volume38
Issue number5
DOIs
Publication statusPublished - 1999 Mar 1
Externally publishedYes

Fingerprint

Enantioselectivity
Alkylation

Keywords

  • Aldehydes
  • Alkylations
  • Asymmetric synthesis
  • Autocatalysis
  • Zinc

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Practically perfect asymmetric autocatalysis with (2-alkynyl-5- pyrimidyl)alkanols. / Shibata, Takanori; Yonekubo, S.; Soai, K.

In: Angewandte Chemie - International Edition, Vol. 38, No. 5, 01.03.1999, p. 659-661.

Research output: Contribution to journalArticle

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