Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

Research output: Contribution to conferencePaper

Abstract

The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Anionio lipid
  • Curcumin
  • Drug delivery
  • Emulsion
  • Lipophilic drug
  • Pharmacokinetics

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Inenaga, S., Sou, K., Takeoka, S., & Tsuchida, E. (2006). Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.