Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages4866
    Number of pages1
    Volume55
    Edition2
    Publication statusPublished - 2006
    Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama
    Duration: 2006 Sep 202006 Sep 22

    Other

    Other55th Society of Polymer Science Japan Symposium on Macromolecules
    CityToyama
    Period06/9/2006/9/22

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    Keywords

    • Anionio lipid
    • Curcumin
    • Drug delivery
    • Emulsion
    • Lipophilic drug
    • Pharmacokinetics

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Inenaga, S., Sou, K., Takeoka, S., & Tsuchida, E. (2006). Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 4866)