Preparation of a series of photoresponsive polymersomes bearing photocleavable a 2-nitrobenzyl group at the hydrophobic/hydrophilic interfaces and their payload releasing behaviors

Shota Yamamoto, Takafumi Yamada, Genki Kubo, Kazuo Sakurai, Kazuo Yamaguchi, Jun Nakanishi

Research output: Contribution to journalArticle


In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation. Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the molecular weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures.

Original languageEnglish
Article number1254
Issue number8
Publication statusPublished - 2019 Jan 1



  • Controlled release
  • Drug delivery
  • Photocleavable diblock copolymer
  • Photoresponsive polymersome
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

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