Preparation of methotrexate-encapsulated liposomes and evaluation of their properties

Kvoko Kaiyama, Izumi Sato, Shinji Takeoka

Research output: Contribution to conferencePaper

Abstract

We are preparing immunoliposomes which encapsulate anticancer methotrexate to provide an efficient intracellular drug delivery system (DDS) in tumor cells. In this paper, concentrated methotrexate was encapsulated into liposomes by an extrusion method. We also evaluated properties of the liposomes such as particle size, encapsulation efficiency, dispersibility, and the leakage of MIX from liposomes.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Anticancer
  • DDS
  • Liposomes
  • Methotrexate
  • Vesicles

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kaiyama, K., Sato, I., & Takeoka, S. (2006). Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.