Preparation of methotrexate-encapsulated liposomes and evaluation of their properties

Kvoko Kaiyama, Izumi Sato, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We are preparing immunoliposomes which encapsulate anticancer methotrexate to provide an efficient intracellular drug delivery system (DDS) in tumor cells. In this paper, concentrated methotrexate was encapsulated into liposomes by an extrusion method. We also evaluated properties of the liposomes such as particle size, encapsulation efficiency, dispersibility, and the leakage of MIX from liposomes.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages4919
    Number of pages1
    Volume55
    Edition2
    Publication statusPublished - 2006
    Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama
    Duration: 2006 Sep 202006 Sep 22

    Other

    Other55th Society of Polymer Science Japan Symposium on Macromolecules
    CityToyama
    Period06/9/2006/9/22

    Fingerprint

    Liposomes
    Encapsulation
    Extrusion
    Tumors
    Particle size
    Cells

    Keywords

    • Anticancer
    • DDS
    • Liposomes
    • Methotrexate
    • Vesicles

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Kaiyama, K., Sato, I., & Takeoka, S. (2006). Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 4919)

    Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. / Kaiyama, Kvoko; Sato, Izumi; Takeoka, Shinji.

    Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 4919.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Kaiyama, K, Sato, I & Takeoka, S 2006, Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 4919, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 06/9/20.
    Kaiyama K, Sato I, Takeoka S. Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 4919
    Kaiyama, Kvoko ; Sato, Izumi ; Takeoka, Shinji. / Preparation of methotrexate-encapsulated liposomes and evaluation of their properties. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 4919
    @inproceedings{5ea38e4a54ea4f05a6159da470500efe,
    title = "Preparation of methotrexate-encapsulated liposomes and evaluation of their properties",
    abstract = "We are preparing immunoliposomes which encapsulate anticancer methotrexate to provide an efficient intracellular drug delivery system (DDS) in tumor cells. In this paper, concentrated methotrexate was encapsulated into liposomes by an extrusion method. We also evaluated properties of the liposomes such as particle size, encapsulation efficiency, dispersibility, and the leakage of MIX from liposomes.",
    keywords = "Anticancer, DDS, Liposomes, Methotrexate, Vesicles",
    author = "Kvoko Kaiyama and Izumi Sato and Shinji Takeoka",
    year = "2006",
    language = "English",
    volume = "55",
    pages = "4919",
    booktitle = "Polymer Preprints, Japan",
    edition = "2",

    }

    TY - GEN

    T1 - Preparation of methotrexate-encapsulated liposomes and evaluation of their properties

    AU - Kaiyama, Kvoko

    AU - Sato, Izumi

    AU - Takeoka, Shinji

    PY - 2006

    Y1 - 2006

    N2 - We are preparing immunoliposomes which encapsulate anticancer methotrexate to provide an efficient intracellular drug delivery system (DDS) in tumor cells. In this paper, concentrated methotrexate was encapsulated into liposomes by an extrusion method. We also evaluated properties of the liposomes such as particle size, encapsulation efficiency, dispersibility, and the leakage of MIX from liposomes.

    AB - We are preparing immunoliposomes which encapsulate anticancer methotrexate to provide an efficient intracellular drug delivery system (DDS) in tumor cells. In this paper, concentrated methotrexate was encapsulated into liposomes by an extrusion method. We also evaluated properties of the liposomes such as particle size, encapsulation efficiency, dispersibility, and the leakage of MIX from liposomes.

    KW - Anticancer

    KW - DDS

    KW - Liposomes

    KW - Methotrexate

    KW - Vesicles

    UR - http://www.scopus.com/inward/record.url?scp=33846169451&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=33846169451&partnerID=8YFLogxK

    M3 - Conference contribution

    AN - SCOPUS:33846169451

    VL - 55

    SP - 4919

    BT - Polymer Preprints, Japan

    ER -