Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai, Ryouta Araki, Kazue Hiraka, Shoichiro Asayama, Shoji Nagaoka, Tomomi Hatsugai, Akihiko Ogata, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2 - · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages2151
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CityYokohama
Period05/5/2505/5/27

Fingerprint

Liposomes
Cells
Porphyrins
Cell death
Iron

Keywords

  • Anticancer drug
  • Drug delivery system
  • Liposome
  • Metalloporphyrin

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Tamai, M., Araki, R., Hiraka, K., Asayama, S., Nagaoka, S., Hatsugai, T., ... Kawakami, H. (2005). Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2151)

Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. / Tamai, Miho; Araki, Ryouta; Hiraka, Kazue; Asayama, Shoichiro; Nagaoka, Shoji; Hatsugai, Tomomi; Ogata, Akihiko; Oyaizu, Kenichi; Yuasa, Makoto; Kawakami, Hiroyoshi.

Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 2151.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tamai, M, Araki, R, Hiraka, K, Asayama, S, Nagaoka, S, Hatsugai, T, Ogata, A, Oyaizu, K, Yuasa, M & Kawakami, H 2005, Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. in Polymer Preprints, Japan. 1 edn, vol. 54, pp. 2151, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
Tamai M, Araki R, Hiraka K, Asayama S, Nagaoka S, Hatsugai T et al. Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. In Polymer Preprints, Japan. 1 ed. Vol. 54. 2005. p. 2151
Tamai, Miho ; Araki, Ryouta ; Hiraka, Kazue ; Asayama, Shoichiro ; Nagaoka, Shoji ; Hatsugai, Tomomi ; Ogata, Akihiko ; Oyaizu, Kenichi ; Yuasa, Makoto ; Kawakami, Hiroyoshi. / Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 2151
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AU - Araki, Ryouta

AU - Hiraka, Kazue

AU - Asayama, Shoichiro

AU - Nagaoka, Shoji

AU - Hatsugai, Tomomi

AU - Ogata, Akihiko

AU - Oyaizu, Kenichi

AU - Yuasa, Makoto

AU - Kawakami, Hiroyoshi

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