Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai, Ryouta Araki, Kazue Hiraka, Shoichiro Asayama, Shoji Nagaoka, Tomomi Hatsugai, Akihiko Ogata, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

Research output: Contribution to conferencePaper

Abstract

We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Anticancer drug
  • Drug delivery system
  • Liposome
  • Metalloporphyrin

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Tamai, M., Araki, R., Hiraka, K., Asayama, S., Nagaoka, S., Hatsugai, T., Ogata, A., Oyaizu, K., Yuasa, M., & Kawakami, H. (2005). Preparation of nanocarriers containing SOD mimics and their anticancer mechanism. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.