Preparation of pH-responsive liposomes with aminolipids

Yosuke Obata, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The development of gene delivery technologies is required using novel nonviral lipids. In this paper, we synthesized hydrolysis of the lipids from amino acids. Our synthesized hydrolysis of the lipids have glutamic acid or lysine skeleton as a hydrophobic part and have glutamic acid as a hydrophilic part. We studied the release of fluorescent from liposome induced by the hydrolysis of the amino lipids. We reported the synthetic methods of the lipids and evaluated the characteristics of the lipids. Furthermore, we prepared liposomes having the amino lipids as a part of membrane components and evaluated their release of liposomes.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages4943-4944
    Number of pages2
    Volume54
    Edition2
    Publication statusPublished - 2005
    Event54th SPSJ Symposium on Macromolecules - Yamagata
    Duration: 2005 Sep 202005 Sep 22

    Other

    Other54th SPSJ Symposium on Macromolecules
    CityYamagata
    Period05/9/2005/9/22

    Fingerprint

    Liposomes
    Lipids
    Hydrolysis
    Acids
    Amino acids
    Genes
    Membranes

    Keywords

    • Amino lipid
    • Drug delivery
    • Liposome

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Obata, Y., & Takeoka, S. (2005). Preparation of pH-responsive liposomes with aminolipids. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 4943-4944)

    Preparation of pH-responsive liposomes with aminolipids. / Obata, Yosuke; Takeoka, Shinji.

    Polymer Preprints, Japan. Vol. 54 2. ed. 2005. p. 4943-4944.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Obata, Y & Takeoka, S 2005, Preparation of pH-responsive liposomes with aminolipids. in Polymer Preprints, Japan. 2 edn, vol. 54, pp. 4943-4944, 54th SPSJ Symposium on Macromolecules, Yamagata, 05/9/20.
    Obata Y, Takeoka S. Preparation of pH-responsive liposomes with aminolipids. In Polymer Preprints, Japan. 2 ed. Vol. 54. 2005. p. 4943-4944
    Obata, Yosuke ; Takeoka, Shinji. / Preparation of pH-responsive liposomes with aminolipids. Polymer Preprints, Japan. Vol. 54 2. ed. 2005. pp. 4943-4944
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