Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes

Yosuke Obata, Daisuke Suzuki, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have developed amino lipids as pH-sensitive components of liposomes because of their low costs and low toxicities. Liposomes are required not only to control the behavior in circulation but also to control the release behavior of encapsulated drugs. We designed zwitter-ionic lipid from glutamic acid as a pH-sensitive lipid. The pH-sensitive lipid changes the head-group charge according to pH. We prepared pH-sensitive liposomes composed of the synthesized pH-sensitive amino lipid and studied the release behavior of albumin from the liposome under low pH and revealed the dynamics in fibroblast cells (CCD-32SK).

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages1949
    Number of pages1
    Volume55
    Edition1
    Publication statusPublished - 2006
    Event55th SPSJ Annual Meeting - Nagoya
    Duration: 2006 May 242006 May 26

    Other

    Other55th SPSJ Annual Meeting
    CityNagoya
    Period06/5/2406/5/26

    Fingerprint

    Liposomes
    Macromolecules
    Lipids
    Fibroblasts
    Charge coupled devices
    Toxicity
    Cells
    Acids
    Costs

    Keywords

    • Amino lipids
    • Controlled release
    • Drug delivery system
    • Liposome
    • PH-sensitive

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes. / Obata, Yosuke; Suzuki, Daisuke; Takeoka, Shinji.

    Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 1949.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Obata, Y, Suzuki, D & Takeoka, S 2006, Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes. in Polymer Preprints, Japan. 1 edn, vol. 55, pp. 1949, 55th SPSJ Annual Meeting, Nagoya, 06/5/24.
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