Preparation of pH-sensitive liposomes retaining SOD mimic and their anticancer effect

Kazue Hiraka, Mayuko Kanehisa, Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We prepared an anticancer drug based on a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe-porphyrin, 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine, dimethylditetradecylammonium bromide, sodium oleate, and Tween-80. The Fe-porphyrin was released from the liposome at low pH, and the cytotoxicity for cancer cells by the liposome depended on the acidic environments of the endosomes in the cells. Furthermore, although the liposome exhibited an excellent anticancer effect on a gastric cancer cell line, the SOD activity of Fe-porphyrin was shown to have a significant influence on the cytotoxicity toward cancer cells. These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume67
Issue number1
DOIs
Publication statusPublished - 2008 Nov 15
Externally publishedYes

Keywords

  • Anticancer
  • Endosomal escape
  • Fe-porphyrin
  • SOD mimic
  • pH-sensitive liposome

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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