Preparation of wettability modulated thermoresponsive surfaces by ATRP and elution control of biomolecules

Naokazu Idota, Akihiko Kikuchi, Jun Kobayashi, Kiyotaka Sakai, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Temperature-dependent aqueous wettability of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces was regulated by thickness of graft polymer layer and architecture of polymer chains utilizing surface-initiated atom transfer radical polymerization (ATRP). Hydrophilic property on the PIPAAm-grafted surfaces depends on polymer layer thickness at low temperature range. More hydrophobic surface properties were observed for poly (n-butyl methacrylate) (PBMA)-b-PIPAAm-grafted surfaces above PIPAAm's transition temperature. Applying surface-initiated ATRP of IPAAm to inner surfaces of microcapillaries, the retention times of steroids were controlled solely by temperature changes. Testosterone showed stronger interaction with more hydrophobic PBMA-e-PIPAAm-grafted surfaces above PIPAAm's LCST, and baseline separation of steroids was successfully achieved within 10min by only temperature alterations.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages5147-5148
Number of pages2
Volume54
Edition2
Publication statusPublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CityYamagata
Period05/9/2005/9/22

Keywords

  • Atom transfer radical polymerization
  • Block copolymer
  • Glass capillary
  • Hydrophobic interaction
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Idota, N., Kikuchi, A., Kobayashi, J., Sakai, K., & Okano, T. (2005). Preparation of wettability modulated thermoresponsive surfaces by ATRP and elution control of biomolecules. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 5147-5148)