Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum

M. Takahashi, K. Shiota, Y. Suzuki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations increased in peripheral blood until day 5, after which concentrations gradually decreased. Removal of the in situ pituitary on day 0 or 1 resulted in maintenance of luteal function; progesterone concentrations were sustained. This effect of hypophysectomy on day 0 was prevented by daily administration of small amounts of LH from days 0-5; however, luteal regression occurred if hypophysectomy was performed on day 4 or later and progesterone concentrations decreased. Luteal regression was prevented if anti-LH serum was administered from days 1-5 to pituitary-isografted rats and was followed by hypophysectomy on day 5. These results indicate that the lifespan of corpora lutea in pseudopregnant rats is programmed between days 2-4 after ovulation through the hypothalamohypophysial axis via secretion of LH.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalEndocrinology
Volume102
Issue number2
Publication statusPublished - 1978
Externally publishedYes

Fingerprint

Corpus Luteum
Luteinizing Hormone
Ovulation
Luteolysis
Hypophysectomy
Progesterone
Corpus Luteum Maintenance
Pseudopregnancy
Capsules
Kidney
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum. / Takahashi, M.; Shiota, K.; Suzuki, Y.

In: Endocrinology, Vol. 102, No. 2, 1978, p. 494-498.

Research output: Contribution to journalArticle

Takahashi, M. ; Shiota, K. ; Suzuki, Y. / Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum. In: Endocrinology. 1978 ; Vol. 102, No. 2. pp. 494-498.
@article{e77019c88bf44a74b62598e18abece70,
title = "Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum",
abstract = "Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations increased in peripheral blood until day 5, after which concentrations gradually decreased. Removal of the in situ pituitary on day 0 or 1 resulted in maintenance of luteal function; progesterone concentrations were sustained. This effect of hypophysectomy on day 0 was prevented by daily administration of small amounts of LH from days 0-5; however, luteal regression occurred if hypophysectomy was performed on day 4 or later and progesterone concentrations decreased. Luteal regression was prevented if anti-LH serum was administered from days 1-5 to pituitary-isografted rats and was followed by hypophysectomy on day 5. These results indicate that the lifespan of corpora lutea in pseudopregnant rats is programmed between days 2-4 after ovulation through the hypothalamohypophysial axis via secretion of LH.",
author = "M. Takahashi and K. Shiota and Y. Suzuki",
year = "1978",
language = "English",
volume = "102",
pages = "494--498",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum

AU - Takahashi, M.

AU - Shiota, K.

AU - Suzuki, Y.

PY - 1978

Y1 - 1978

N2 - Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations increased in peripheral blood until day 5, after which concentrations gradually decreased. Removal of the in situ pituitary on day 0 or 1 resulted in maintenance of luteal function; progesterone concentrations were sustained. This effect of hypophysectomy on day 0 was prevented by daily administration of small amounts of LH from days 0-5; however, luteal regression occurred if hypophysectomy was performed on day 4 or later and progesterone concentrations decreased. Luteal regression was prevented if anti-LH serum was administered from days 1-5 to pituitary-isografted rats and was followed by hypophysectomy on day 5. These results indicate that the lifespan of corpora lutea in pseudopregnant rats is programmed between days 2-4 after ovulation through the hypothalamohypophysial axis via secretion of LH.

AB - Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations increased in peripheral blood until day 5, after which concentrations gradually decreased. Removal of the in situ pituitary on day 0 or 1 resulted in maintenance of luteal function; progesterone concentrations were sustained. This effect of hypophysectomy on day 0 was prevented by daily administration of small amounts of LH from days 0-5; however, luteal regression occurred if hypophysectomy was performed on day 4 or later and progesterone concentrations decreased. Luteal regression was prevented if anti-LH serum was administered from days 1-5 to pituitary-isografted rats and was followed by hypophysectomy on day 5. These results indicate that the lifespan of corpora lutea in pseudopregnant rats is programmed between days 2-4 after ovulation through the hypothalamohypophysial axis via secretion of LH.

UR - http://www.scopus.com/inward/record.url?scp=0018097630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018097630&partnerID=8YFLogxK

M3 - Article

VL - 102

SP - 494

EP - 498

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 2

ER -