Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: A 2-year longitudinal study

Tsuyoshi Suzuki, Tsuyoshi Shiga, Kazue Kuwahara, Sayaka Kobayashi, Shinichi Suzuki, Katsuji Nishimura, Atsushi Suzuki, Koichiro Ejima, Tetsuyuki Manaka, Morio Shoda, Jun Ishigooka, Hiroshi Kasanuki, Nobuhisa Hagiwara

    Research output: Contribution to journalArticle

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    Abstract

    Background: It is unclear whether depression persists in patients with implantable cardioverter defibrillators (ICDs). We evaluated the prevalence and persistence of depression in ICD patients over a 2-year period. Methods: The study included 90 consecutively hospitalized patients. Patients underlying heart disease was 24% coronary artery disease, 29% idiopathic dilated cardiomyopathy, 24% hypertrophic cardiomyopathy, 13% idiopathic VF/long QT syndrome and miscellaneous conditions 11%. A secondary indication for ICD implantation was present in 20 patients. All patients completed the Zung Self-Rating Depression Scale (SDS) at study baseline and at the their routine follow-up visit 2 years after the baseline questionnaire. Delivery of ICD therapies was tracked throughout the 2 years. Results: Depression, indicated by a Zung SDS index score exceeding 60, was present in 29 (32%) of patients at study baseline. Depression was present in 11/51 (21%) patients scheduled to undergo ICD implantation, 2/2 (100%) patients whose device was upgraded to a CRT-D, 3/14 (21%) patients who had undergone pulse generator replacement, 7/14 (50%) patients who experienced electrical storm and 6/9 (66%) patients hospitalized with acute decompensated heart failure. NYHA functional class III was significantly associated with depression at baseline (HR 6.7, 95% CI 1.68-27.2, p = 0.0007). No differences were noted for female gender, demographics, β-blocker use, or LVEF ≤35% (p = ns). Depression was present in 25 (28%) of patients at 2 years follow-up, persisting in 21 (72%) of patients whose Zung SDS scores were elevated at baseline. The median time from ICD shock therapy to completion of the 2 year questionnaire was 9 months (range, 1-22). Patients who were depressed (9/25, 36%) experienced more shocks than non-depressed patients (6/65, 9%) after 2 years (p = 0.002). Conclusions: Depression is not uncommon among patients who meet criteria for ICD implantation and persists over time particularly when functional status is impaired. Depression is associated with a higher incidence shock therapy.

    Original languageEnglish
    Pages (from-to)1455-1461
    Number of pages7
    JournalPACE - Pacing and Clinical Electrophysiology
    Volume33
    Issue number12
    DOIs
    Publication statusPublished - 2010 Dec

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    Implantable Defibrillators
    varespladib methyl
    Longitudinal Studies
    Depression
    Convulsive Therapy
    Long QT Syndrome
    Hypertrophic Cardiomyopathy
    Dilated Cardiomyopathy

    Keywords

    • depression
    • implantable cardioverter defibrillator
    • shock

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Prevalence and persistence of depression in patients with implantable cardioverter defibrillator : A 2-year longitudinal study. / Suzuki, Tsuyoshi; Shiga, Tsuyoshi; Kuwahara, Kazue; Kobayashi, Sayaka; Suzuki, Shinichi; Nishimura, Katsuji; Suzuki, Atsushi; Ejima, Koichiro; Manaka, Tetsuyuki; Shoda, Morio; Ishigooka, Jun; Kasanuki, Hiroshi; Hagiwara, Nobuhisa.

    In: PACE - Pacing and Clinical Electrophysiology, Vol. 33, No. 12, 12.2010, p. 1455-1461.

    Research output: Contribution to journalArticle

    Suzuki, T, Shiga, T, Kuwahara, K, Kobayashi, S, Suzuki, S, Nishimura, K, Suzuki, A, Ejima, K, Manaka, T, Shoda, M, Ishigooka, J, Kasanuki, H & Hagiwara, N 2010, 'Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: A 2-year longitudinal study', PACE - Pacing and Clinical Electrophysiology, vol. 33, no. 12, pp. 1455-1461. https://doi.org/10.1111/j.1540-8159.2010.02887.x
    Suzuki, Tsuyoshi ; Shiga, Tsuyoshi ; Kuwahara, Kazue ; Kobayashi, Sayaka ; Suzuki, Shinichi ; Nishimura, Katsuji ; Suzuki, Atsushi ; Ejima, Koichiro ; Manaka, Tetsuyuki ; Shoda, Morio ; Ishigooka, Jun ; Kasanuki, Hiroshi ; Hagiwara, Nobuhisa. / Prevalence and persistence of depression in patients with implantable cardioverter defibrillator : A 2-year longitudinal study. In: PACE - Pacing and Clinical Electrophysiology. 2010 ; Vol. 33, No. 12. pp. 1455-1461.
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    abstract = "Background: It is unclear whether depression persists in patients with implantable cardioverter defibrillators (ICDs). We evaluated the prevalence and persistence of depression in ICD patients over a 2-year period. Methods: The study included 90 consecutively hospitalized patients. Patients underlying heart disease was 24{\%} coronary artery disease, 29{\%} idiopathic dilated cardiomyopathy, 24{\%} hypertrophic cardiomyopathy, 13{\%} idiopathic VF/long QT syndrome and miscellaneous conditions 11{\%}. A secondary indication for ICD implantation was present in 20 patients. All patients completed the Zung Self-Rating Depression Scale (SDS) at study baseline and at the their routine follow-up visit 2 years after the baseline questionnaire. Delivery of ICD therapies was tracked throughout the 2 years. Results: Depression, indicated by a Zung SDS index score exceeding 60, was present in 29 (32{\%}) of patients at study baseline. Depression was present in 11/51 (21{\%}) patients scheduled to undergo ICD implantation, 2/2 (100{\%}) patients whose device was upgraded to a CRT-D, 3/14 (21{\%}) patients who had undergone pulse generator replacement, 7/14 (50{\%}) patients who experienced electrical storm and 6/9 (66{\%}) patients hospitalized with acute decompensated heart failure. NYHA functional class III was significantly associated with depression at baseline (HR 6.7, 95{\%} CI 1.68-27.2, p = 0.0007). No differences were noted for female gender, demographics, β-blocker use, or LVEF ≤35{\%} (p = ns). Depression was present in 25 (28{\%}) of patients at 2 years follow-up, persisting in 21 (72{\%}) of patients whose Zung SDS scores were elevated at baseline. The median time from ICD shock therapy to completion of the 2 year questionnaire was 9 months (range, 1-22). Patients who were depressed (9/25, 36{\%}) experienced more shocks than non-depressed patients (6/65, 9{\%}) after 2 years (p = 0.002). Conclusions: Depression is not uncommon among patients who meet criteria for ICD implantation and persists over time particularly when functional status is impaired. Depression is associated with a higher incidence shock therapy.",
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    AU - Shiga, Tsuyoshi

    AU - Kuwahara, Kazue

    AU - Kobayashi, Sayaka

    AU - Suzuki, Shinichi

    AU - Nishimura, Katsuji

    AU - Suzuki, Atsushi

    AU - Ejima, Koichiro

    AU - Manaka, Tetsuyuki

    AU - Shoda, Morio

    AU - Ishigooka, Jun

    AU - Kasanuki, Hiroshi

    AU - Hagiwara, Nobuhisa

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    N2 - Background: It is unclear whether depression persists in patients with implantable cardioverter defibrillators (ICDs). We evaluated the prevalence and persistence of depression in ICD patients over a 2-year period. Methods: The study included 90 consecutively hospitalized patients. Patients underlying heart disease was 24% coronary artery disease, 29% idiopathic dilated cardiomyopathy, 24% hypertrophic cardiomyopathy, 13% idiopathic VF/long QT syndrome and miscellaneous conditions 11%. A secondary indication for ICD implantation was present in 20 patients. All patients completed the Zung Self-Rating Depression Scale (SDS) at study baseline and at the their routine follow-up visit 2 years after the baseline questionnaire. Delivery of ICD therapies was tracked throughout the 2 years. Results: Depression, indicated by a Zung SDS index score exceeding 60, was present in 29 (32%) of patients at study baseline. Depression was present in 11/51 (21%) patients scheduled to undergo ICD implantation, 2/2 (100%) patients whose device was upgraded to a CRT-D, 3/14 (21%) patients who had undergone pulse generator replacement, 7/14 (50%) patients who experienced electrical storm and 6/9 (66%) patients hospitalized with acute decompensated heart failure. NYHA functional class III was significantly associated with depression at baseline (HR 6.7, 95% CI 1.68-27.2, p = 0.0007). No differences were noted for female gender, demographics, β-blocker use, or LVEF ≤35% (p = ns). Depression was present in 25 (28%) of patients at 2 years follow-up, persisting in 21 (72%) of patients whose Zung SDS scores were elevated at baseline. The median time from ICD shock therapy to completion of the 2 year questionnaire was 9 months (range, 1-22). Patients who were depressed (9/25, 36%) experienced more shocks than non-depressed patients (6/65, 9%) after 2 years (p = 0.002). Conclusions: Depression is not uncommon among patients who meet criteria for ICD implantation and persists over time particularly when functional status is impaired. Depression is associated with a higher incidence shock therapy.

    AB - Background: It is unclear whether depression persists in patients with implantable cardioverter defibrillators (ICDs). We evaluated the prevalence and persistence of depression in ICD patients over a 2-year period. Methods: The study included 90 consecutively hospitalized patients. Patients underlying heart disease was 24% coronary artery disease, 29% idiopathic dilated cardiomyopathy, 24% hypertrophic cardiomyopathy, 13% idiopathic VF/long QT syndrome and miscellaneous conditions 11%. A secondary indication for ICD implantation was present in 20 patients. All patients completed the Zung Self-Rating Depression Scale (SDS) at study baseline and at the their routine follow-up visit 2 years after the baseline questionnaire. Delivery of ICD therapies was tracked throughout the 2 years. Results: Depression, indicated by a Zung SDS index score exceeding 60, was present in 29 (32%) of patients at study baseline. Depression was present in 11/51 (21%) patients scheduled to undergo ICD implantation, 2/2 (100%) patients whose device was upgraded to a CRT-D, 3/14 (21%) patients who had undergone pulse generator replacement, 7/14 (50%) patients who experienced electrical storm and 6/9 (66%) patients hospitalized with acute decompensated heart failure. NYHA functional class III was significantly associated with depression at baseline (HR 6.7, 95% CI 1.68-27.2, p = 0.0007). No differences were noted for female gender, demographics, β-blocker use, or LVEF ≤35% (p = ns). Depression was present in 25 (28%) of patients at 2 years follow-up, persisting in 21 (72%) of patients whose Zung SDS scores were elevated at baseline. The median time from ICD shock therapy to completion of the 2 year questionnaire was 9 months (range, 1-22). Patients who were depressed (9/25, 36%) experienced more shocks than non-depressed patients (6/65, 9%) after 2 years (p = 0.002). Conclusions: Depression is not uncommon among patients who meet criteria for ICD implantation and persists over time particularly when functional status is impaired. Depression is associated with a higher incidence shock therapy.

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