Printing support hydrogels for creating vascular-like structures in stacked cell sheets

Research output: Contribution to journalArticle

Abstract

Vascular structures are essential for the survival of thick artificial three-dimensional (3D) tissues. However, it is difficult to create high-cell-density artificial tissue with vascular structures of a few hundred micrometers in diameter. Bioprinting technology can create artificial 3D tissues with vascular structures of a few hundred micrometers in diameter, but the cell density of bio-printed artificial 3D tissues is low. On the other hand, cell sheet technology can create high-cell-density artificial 3D tissues by stacking, but it is not possible to set small vascular structures at any place. In this study, we successfully demonstrated high-cell-density artificial 3D tissues with vascular-like structures by stacking cell sheets combined with bioprinting technology.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalArtificial Life and Robotics
Volume25
Issue number2
DOIs
Publication statusPublished - 2020 May 1

Keywords

  • Bioprinting
  • Cell sheet
  • Support hydrogel
  • Vascular-like structure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Artificial Intelligence

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