TY - JOUR
T1 - Printing support hydrogels for creating vascular-like structures in stacked cell sheets
AU - Tanaka, Ryu ichiro
AU - Sakaguchi, Katsuhisa
AU - Umezu, Shinjiro
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (no. 18K18838) and Japan Science and Technology Agency (no. JPMJMI18CD).
Publisher Copyright:
© 2020, International Society of Artificial Life and Robotics (ISAROB).
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Vascular structures are essential for the survival of thick artificial three-dimensional (3D) tissues. However, it is difficult to create high-cell-density artificial tissue with vascular structures of a few hundred micrometers in diameter. Bioprinting technology can create artificial 3D tissues with vascular structures of a few hundred micrometers in diameter, but the cell density of bio-printed artificial 3D tissues is low. On the other hand, cell sheet technology can create high-cell-density artificial 3D tissues by stacking, but it is not possible to set small vascular structures at any place. In this study, we successfully demonstrated high-cell-density artificial 3D tissues with vascular-like structures by stacking cell sheets combined with bioprinting technology.
AB - Vascular structures are essential for the survival of thick artificial three-dimensional (3D) tissues. However, it is difficult to create high-cell-density artificial tissue with vascular structures of a few hundred micrometers in diameter. Bioprinting technology can create artificial 3D tissues with vascular structures of a few hundred micrometers in diameter, but the cell density of bio-printed artificial 3D tissues is low. On the other hand, cell sheet technology can create high-cell-density artificial 3D tissues by stacking, but it is not possible to set small vascular structures at any place. In this study, we successfully demonstrated high-cell-density artificial 3D tissues with vascular-like structures by stacking cell sheets combined with bioprinting technology.
KW - Bioprinting
KW - Cell sheet
KW - Support hydrogel
KW - Vascular-like structure
UR - http://www.scopus.com/inward/record.url?scp=85083434508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083434508&partnerID=8YFLogxK
U2 - 10.1007/s10015-020-00605-7
DO - 10.1007/s10015-020-00605-7
M3 - Article
AN - SCOPUS:85083434508
VL - 25
SP - 199
EP - 203
JO - Artificial Life and Robotics
JF - Artificial Life and Robotics
SN - 1433-5298
IS - 2
ER -