Production of LLU-α following an oral administration of χ-tocotrienol or χ-tocopherol to rats

Akihiro Hattori, Takeshi Fukushima, Hiroyuki Yoshimura, Kouichi Abe, Kazuhiro Imai

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

An oral administration of χ-tocotrienol (χ-T3) or χ-tocopherol (χ-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (LLU-α, χ-CEHC), a natriuretic compound, in plasma with a T(m)(a)(x) of 9 h. The configuration at C-2 of LLU-α produced from χ-T3 or χ-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-α was produced not only from χ-Toc but also χ-T3, without racemization at C-2 in rats.

Original languageEnglish
Pages (from-to)1395-1397
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume23
Issue number11
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • χ-tocopherol
  • χ-tocotrienol
  • HPLC
  • LLU-α(χ-CEHC)
  • Rat plasma

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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