Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes

J. G. Metz, P. Roessler, D. Facciotti, C. Levering, F. Dittrich, M. Lassner, R. Valentine, K. Lardizabal, F. Domergue, A. Yamada, Kazunaga Yazawa, V. Knauf, J. Browse

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

Polyunsaturated fatty acids (PUFAs) are essential membrane components in higher eukaryotes and are the precursors of many lipid-derived signaling molecules. Here, pathways for PUFA synthesis are described that do not require desaturation and elongation of saturated fatty acids. These pathways are catalyzed by polyketide synthases (PKSs) that are distinct from previously recognized PKSs in both structure and mechanism. Generation of cis double bonds probably involves position-specific isomerases; such enzymes might be useful in the production of new families of antibiotics. It is likely that PUFA synthesis in cold marine ecosystems is accomplished in part by these PKS enzymes.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalScience
Volume293
Issue number5528
DOIs
Publication statusPublished - 2001 Jul 13
Externally publishedYes

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Polyketide Synthases
Fatty Acid Synthases
Eukaryota
Unsaturated Fatty Acids
Isomerases
Enzymes
Ecosystem
Fatty Acids
Anti-Bacterial Agents
Lipids
Membranes

ASJC Scopus subject areas

  • General

Cite this

Metz, J. G., Roessler, P., Facciotti, D., Levering, C., Dittrich, F., Lassner, M., ... Browse, J. (2001). Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. Science, 293(5528), 290-293. https://doi.org/10.1126/science.1059593

Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. / Metz, J. G.; Roessler, P.; Facciotti, D.; Levering, C.; Dittrich, F.; Lassner, M.; Valentine, R.; Lardizabal, K.; Domergue, F.; Yamada, A.; Yazawa, Kazunaga; Knauf, V.; Browse, J.

In: Science, Vol. 293, No. 5528, 13.07.2001, p. 290-293.

Research output: Contribution to journalArticle

Metz, JG, Roessler, P, Facciotti, D, Levering, C, Dittrich, F, Lassner, M, Valentine, R, Lardizabal, K, Domergue, F, Yamada, A, Yazawa, K, Knauf, V & Browse, J 2001, 'Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes', Science, vol. 293, no. 5528, pp. 290-293. https://doi.org/10.1126/science.1059593
Metz JG, Roessler P, Facciotti D, Levering C, Dittrich F, Lassner M et al. Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. Science. 2001 Jul 13;293(5528):290-293. https://doi.org/10.1126/science.1059593
Metz, J. G. ; Roessler, P. ; Facciotti, D. ; Levering, C. ; Dittrich, F. ; Lassner, M. ; Valentine, R. ; Lardizabal, K. ; Domergue, F. ; Yamada, A. ; Yazawa, Kazunaga ; Knauf, V. ; Browse, J. / Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. In: Science. 2001 ; Vol. 293, No. 5528. pp. 290-293.
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