Prognostic factors for epileptic seizures in severe motor and intellectual disabilities syndrome (SMIDS)-A clinical and electroencephalographic study

Akiko Matsumoto, Shuji Miyazaki, Chiemi Hayakawa, Taku Komori, Miho Nakamura, Atsushi Oshio

Research output: Contribution to journalArticle

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Abstract

Purpose: The purpose of this study is to examine prognostic factors for seizures in 106 epileptic patients with SMIDS. Subjects and methods: One-hundred-six epileptic patients with SMIDS were the subjects of this study. The study group consisted of 60 male and 46 female patients. The ages ranged from 4 to 61 years. They were all followed up for more than 4 years in our residential facility hospital "Kobato Gakuen". Fourteen possible prognostic factors were investigated statistically, and the validity is studied by factor analysis (principal component method). Results: Statistically significant poor prognostic factors for epileptic seizures in SMIDS were (1) status epilepticus; (2) multifocal spikes (MFS) or Diffuse spike and waves (DSW) on final EEG; (3) symptomatic generalized epilepsy; (4) MFS or DSW on first EEG; (5) multi-antiepileptic drugs; (6) postnatal etiology; and (7) short duration of institutional hospitalization. As a result of factor analysis, the following five factors are elucidated: (1) Age/Time Passage; (2) Status epilepticus/Etiology; (3) Epileptic syndrome/EEG; (4) intensive medical care; and (5) Severity of Disabilities/Gender. Conclusion: Our findings indicate that intractability of epilepsy may be identified early in the course of the disease, even in SMIDS, and EEG and epileptic syndrome are the very important factors for predicting the seizure prognosis.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalEpilepsy Research
Volume86
Issue number2-3
DOIs
Publication statusPublished - 2009 Oct
Externally publishedYes

Fingerprint

Intellectual Disability
Epilepsy
Electroencephalography
Status Epilepticus
Statistical Factor Analysis
Seizures
Residential Facilities
Generalized Epilepsy
Critical Care
Anticonvulsants
Clinical Studies
Hospitalization

Keywords

  • Electroencephalography
  • Epilepsy
  • Epileptic syndrome
  • Factor analysis
  • Prognostic factor
  • SMIDS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Prognostic factors for epileptic seizures in severe motor and intellectual disabilities syndrome (SMIDS)-A clinical and electroencephalographic study. / Matsumoto, Akiko; Miyazaki, Shuji; Hayakawa, Chiemi; Komori, Taku; Nakamura, Miho; Oshio, Atsushi.

In: Epilepsy Research, Vol. 86, No. 2-3, 10.2009, p. 175-182.

Research output: Contribution to journalArticle

Matsumoto, Akiko ; Miyazaki, Shuji ; Hayakawa, Chiemi ; Komori, Taku ; Nakamura, Miho ; Oshio, Atsushi. / Prognostic factors for epileptic seizures in severe motor and intellectual disabilities syndrome (SMIDS)-A clinical and electroencephalographic study. In: Epilepsy Research. 2009 ; Vol. 86, No. 2-3. pp. 175-182.
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