Programmable Medicine: Autonomous, Ingestible, Deployable Hydrogel Patch and Plug for Stomach Ulcer Therapy

Alexis Du Plessis D'Argentre, Samuel Perry, Yoshitaka Iwata, Haruna Iwasaki, Eiji Iwase, Assunta Fabozzo, Iain Will, Daniela Rus, Dana D. Damian, Shuhei Miyashita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Gastric ulcer is a chronic and complex (and often complete) erosion of the stomach wall that happens as a complication of a previous chronic, inflammatory process. It represents a catastrophic situation in which the patient is critical and its conditions need to be treated fast. This study presents a remotely navigatable and deployable ingestible patch and plug for gastric ulcer treatment. The patch/plug structure is made of agarose hydrogel that can change rigidity through hydration and dehydration. When dehydrated, it is rigid and can maintain a folded configuration so it can be ingested as a 'pill'. This can be guided to the targeted location by a magnetic field, and be deployed instantly by hydration, namely by supplying water from the mouth. Due to the deployable origami design, it exhibits an expansion of 10 times its initial surface area, making the device suitable for the use of dressing a surface as a patch, and filling a hole as a plug.

Original languageEnglish
Title of host publication2018 IEEE International Conference on Robotics and Automation, ICRA 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1511-1518
Number of pages8
ISBN (Electronic)9781538630815
DOIs
Publication statusPublished - 2018 Sep 10
Event2018 IEEE International Conference on Robotics and Automation, ICRA 2018 - Brisbane, Australia
Duration: 2018 May 212018 May 25

Publication series

NameProceedings - IEEE International Conference on Robotics and Automation
ISSN (Print)1050-4729

Conference

Conference2018 IEEE International Conference on Robotics and Automation, ICRA 2018
CountryAustralia
CityBrisbane
Period18/5/2118/5/25

ASJC Scopus subject areas

  • Software
  • Control and Systems Engineering
  • Artificial Intelligence
  • Electrical and Electronic Engineering

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  • Cite this

    D'Argentre, A. D. P., Perry, S., Iwata, Y., Iwasaki, H., Iwase, E., Fabozzo, A., Will, I., Rus, D., Damian, D. D., & Miyashita, S. (2018). Programmable Medicine: Autonomous, Ingestible, Deployable Hydrogel Patch and Plug for Stomach Ulcer Therapy. In 2018 IEEE International Conference on Robotics and Automation, ICRA 2018 (pp. 1511-1518). [8460615] (Proceedings - IEEE International Conference on Robotics and Automation). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICRA.2018.8460615