Progresses in separation and sensing technologies using DNA as affinity ligands (Review)

Daisuke Umeno, Mizuo Maeda

Research output: Contribution to journalArticlepeer-review

Abstract

The recent developments of affinity techniques concerning single- and double-stranded DNA are reviewed. Based on the opinion that the immobilization of DNA is essential for the analytical and preparative use of the ligand function of DNAs, the two items are extensively discussed concerning the choice of conjugation chemistry and supports. Finally, a variety of applications, mainly for sensing and purification, are discussed.

Original languageEnglish
Pages (from-to)871-890
Number of pages20
JournalBUNSEKI KAGAKU
Volume48
Issue number10
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Affinity separation
  • Bioconjugate
  • Biosensor
  • DNA chip
  • DNA-binding protein
  • Hybrid material
  • Immobilized DNA

ASJC Scopus subject areas

  • Analytical Chemistry

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