Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie, Yousuke Okamura, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages1925
Number of pages1
Volume55
Edition1
Publication statusPublished - 2006
Event55th SPSJ Annual Meeting - Nagoya
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CityNagoya
Period06/5/2406/5/26

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Platelets
Amino acids
Rats

Keywords

  • Blood circulation clearance
  • Fibrinogen γ chain dodecapeptide (H12)
  • Hemostatic effect
  • Platelet substitutes
  • Polyethyleneglycol

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes. / Fujie, Toshinori; Okamura, Yousuke; Takeoka, Shinji; Handa, Makoto; Ikeda, Yasuo.

Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 1925.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fujie, T, Okamura, Y, Takeoka, S, Handa, M & Ikeda, Y 2006, Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes. in Polymer Preprints, Japan. 1 edn, vol. 55, pp. 1925, 55th SPSJ Annual Meeting, Nagoya, 06/5/24.
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