Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie, Yousuke Okamura, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages1925
Number of pages1
Volume55
Edition1
Publication statusPublished - 2006
Event55th SPSJ Annual Meeting - Nagoya
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CityNagoya
Period06/5/2406/5/26

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Keywords

  • Blood circulation clearance
  • Fibrinogen γ chain dodecapeptide (H12)
  • Hemostatic effect
  • Platelet substitutes
  • Polyethyleneglycol

ASJC Scopus subject areas

  • Engineering(all)

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