Properties of follicle-stimulating hormone receptors and changes during annual breeding cycle in the testis of short-tailed bandicoot rat, Nesokia indica

Kazuyoshi Tsutsui, Seiichiro Kawashima, Vishnu Kumar, Reena Kapania, Rajendra N. Saxena

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Some properties and seasonal changes of follicle-stimulating hormone (FSH) receptors in the testis of short-tailed bandicoot rat, Nesokia indica, were studied. The binding of FSH was highly specific for mammalian FSHs and located primarily in the testis. The Scatchard plot analyses of the binding of FSH to the testicular preparations of N. indica showed straight lines similar to those of albino Wistar rats, suggesting the presence of a single class of FSH-binding sites. The mean dissociation constants (Kds) for FSH receptors of N. indica were 1.416 (0.964 - 2.667, 95% confidence interval) nM in December, 1986; 1.348 (0.885 - 2.849) nM in April, 1987; and 3.039 (1.678 - 16.127) nM in August to October, 1987. No significant differences were found among the three groups, but they were all significantly greater than those in Wistar rats. The FSH binding per unit weight of tissue during nonbreeding phase (June, 1987) was lower than those during other phases (December, 1986; April and August-October, 1987). Calculated numbers of FSH-binding sites showed no statistically significant differences among the latter three phases. In June preparations the number of binding sites was not determined due to their extremely low binding capacity.

Original languageEnglish
Pages (from-to)442-451
Number of pages10
JournalGeneral and Comparative Endocrinology
Volume73
Issue number3
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

FSH Receptors
Murinae
follicle-stimulating hormone
Follicle Stimulating Hormone
Breeding
Testis
testes
rats
breeding
binding sites
Binding Sites
Wistar Rats
binding capacity
tissue weight
albino
confidence interval
follicle-stimulating hormone receptors
Confidence Intervals
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology

Cite this

Properties of follicle-stimulating hormone receptors and changes during annual breeding cycle in the testis of short-tailed bandicoot rat, Nesokia indica. / Tsutsui, Kazuyoshi; Kawashima, Seiichiro; Kumar, Vishnu; Kapania, Reena; Saxena, Rajendra N.

In: General and Comparative Endocrinology, Vol. 73, No. 3, 1989, p. 442-451.

Research output: Contribution to journalArticle

@article{2a713beb9aa64851982b5ff70ae4925d,
title = "Properties of follicle-stimulating hormone receptors and changes during annual breeding cycle in the testis of short-tailed bandicoot rat, Nesokia indica",
abstract = "Some properties and seasonal changes of follicle-stimulating hormone (FSH) receptors in the testis of short-tailed bandicoot rat, Nesokia indica, were studied. The binding of FSH was highly specific for mammalian FSHs and located primarily in the testis. The Scatchard plot analyses of the binding of FSH to the testicular preparations of N. indica showed straight lines similar to those of albino Wistar rats, suggesting the presence of a single class of FSH-binding sites. The mean dissociation constants (Kds) for FSH receptors of N. indica were 1.416 (0.964 - 2.667, 95{\%} confidence interval) nM in December, 1986; 1.348 (0.885 - 2.849) nM in April, 1987; and 3.039 (1.678 - 16.127) nM in August to October, 1987. No significant differences were found among the three groups, but they were all significantly greater than those in Wistar rats. The FSH binding per unit weight of tissue during nonbreeding phase (June, 1987) was lower than those during other phases (December, 1986; April and August-October, 1987). Calculated numbers of FSH-binding sites showed no statistically significant differences among the latter three phases. In June preparations the number of binding sites was not determined due to their extremely low binding capacity.",
author = "Kazuyoshi Tsutsui and Seiichiro Kawashima and Vishnu Kumar and Reena Kapania and Saxena, {Rajendra N.}",
year = "1989",
doi = "10.1016/0016-6480(89)90201-3",
language = "English",
volume = "73",
pages = "442--451",
journal = "General and Comparative Endocrinology",
issn = "0016-6480",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Properties of follicle-stimulating hormone receptors and changes during annual breeding cycle in the testis of short-tailed bandicoot rat, Nesokia indica

AU - Tsutsui, Kazuyoshi

AU - Kawashima, Seiichiro

AU - Kumar, Vishnu

AU - Kapania, Reena

AU - Saxena, Rajendra N.

PY - 1989

Y1 - 1989

N2 - Some properties and seasonal changes of follicle-stimulating hormone (FSH) receptors in the testis of short-tailed bandicoot rat, Nesokia indica, were studied. The binding of FSH was highly specific for mammalian FSHs and located primarily in the testis. The Scatchard plot analyses of the binding of FSH to the testicular preparations of N. indica showed straight lines similar to those of albino Wistar rats, suggesting the presence of a single class of FSH-binding sites. The mean dissociation constants (Kds) for FSH receptors of N. indica were 1.416 (0.964 - 2.667, 95% confidence interval) nM in December, 1986; 1.348 (0.885 - 2.849) nM in April, 1987; and 3.039 (1.678 - 16.127) nM in August to October, 1987. No significant differences were found among the three groups, but they were all significantly greater than those in Wistar rats. The FSH binding per unit weight of tissue during nonbreeding phase (June, 1987) was lower than those during other phases (December, 1986; April and August-October, 1987). Calculated numbers of FSH-binding sites showed no statistically significant differences among the latter three phases. In June preparations the number of binding sites was not determined due to their extremely low binding capacity.

AB - Some properties and seasonal changes of follicle-stimulating hormone (FSH) receptors in the testis of short-tailed bandicoot rat, Nesokia indica, were studied. The binding of FSH was highly specific for mammalian FSHs and located primarily in the testis. The Scatchard plot analyses of the binding of FSH to the testicular preparations of N. indica showed straight lines similar to those of albino Wistar rats, suggesting the presence of a single class of FSH-binding sites. The mean dissociation constants (Kds) for FSH receptors of N. indica were 1.416 (0.964 - 2.667, 95% confidence interval) nM in December, 1986; 1.348 (0.885 - 2.849) nM in April, 1987; and 3.039 (1.678 - 16.127) nM in August to October, 1987. No significant differences were found among the three groups, but they were all significantly greater than those in Wistar rats. The FSH binding per unit weight of tissue during nonbreeding phase (June, 1987) was lower than those during other phases (December, 1986; April and August-October, 1987). Calculated numbers of FSH-binding sites showed no statistically significant differences among the latter three phases. In June preparations the number of binding sites was not determined due to their extremely low binding capacity.

UR - http://www.scopus.com/inward/record.url?scp=0024516527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024516527&partnerID=8YFLogxK

U2 - 10.1016/0016-6480(89)90201-3

DO - 10.1016/0016-6480(89)90201-3

M3 - Article

C2 - 2925081

AN - SCOPUS:0024516527

VL - 73

SP - 442

EP - 451

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

IS - 3

ER -