Prostaglandin F metabolite levels in plasma, amniotic fluid, and urine during pregnancy and labor

Kazuo Satoh*, Takehiko Yasumizu, Hideoki Fukuoka, Katsuyuki Kinoshita, Yoshiharu Kaneko, Mitose Tsuchiya, Shoichi Sakamoto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


Levels of 13, 14-dihydro 15-keto-prostaglandin F (dhk PGF) in the plasma of 30 patients as well as in the amniotic fluid of 17 patients, and 5α, 7α-dihydroxy 11-keto tetranor-prostane 1,16-dioic acid (the main urinary metabolite of PGF [PGF MUM]) levels in the urine of 30 patients were measured by radioimmunoassay during pregnancy, labor, and the puerperium. During pregnancy, no increase in dhk PGF (ng/ml) in plasma was detected as the time of delivery approached. The levels of dhk PGF during the second stage (0.64 ± 0.15) and also at delivery (0.88 ± 0.27) were significantly elevated over those in the first stage (0.38 ± 0.29) (P <0.025 and P < 0.005, respectively). Its level 2 hours after delivery was reduced to predelivery levels. Its levels in umbilical arterial and venous blood were 0.71 ± 0.26 and 0.67 ± 0.26, respectively. A significant elevation (P < 0.01) of dhk PGF from 0.89 ± 0.21 before labor to 6.16 ± 2.40 at delivery was found in amniotic fluid. The hourly excretion of PGF MUM (μg/hour) increased significantly from pregnancy levels to 1.06 ± 0.45 in the first stage (P < 0.01), to 7.67 ± 4.31 (P < 0.005) for the first 2 hours after delivery, and 2.37 ± 1.08 from 2 to 12 hours after delivery (P < 0.01). The excretion of PGF MUM decreased to pregnancy levels 12 hours post partum. These data indicate that during labor the production of PGF is remarkably increased.

Original languageEnglish
Pages (from-to)886-890
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number8
Publication statusPublished - 1979 Apr 15
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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