Protein carbonyl content roughly reflects the unsaturation of lipids in muscle but not in other tissues of stroke-prone spontaneously hypertensive strain (SHRSP) rats fed different fats and oils

Akira Sato, Min Zhao Huang, Shiro Watanabe, Harumi Okuyama, Hideko Nakamoto, Zsolt Radak, Sataro Goto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined in vivo the effect of dietary fats and oils with different peroxidizability on protein carbonyl content, the presumed index of free radical-mediated protein oxidation. For 15.6 months, SHRSP (stroke-prone spontaneously hypertensive strain) rats were fed a diet supplemented with lard, safflower oil, perilla oil or fish oil/soybean oil, the peroxidizability of which increases in this order. The peroxidizability of tissue lipids was positively correlated with the protein carbonyl content in skeletal muscle, but not in the brain, heart or liver. The protein carbonyl content in the lard group was higher in the brain and liver compared to the other dietary groups. These results contradict the concept that long-term feeding of easily autoxidizable fatty acids allows the accumulation of lipid peroxides to accelerate the development of the free radical diseases, and suggest that tissue protein carbonyl content is not a simple reflection of autoxidizability-related lipid peroxidation but is also influenced by other biochemical processes.

Original languageEnglish
Pages (from-to)1271-1276
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume21
Issue number12
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

Fingerprint

Oils
Stroke
Fats
Lipids
Muscles
Proteins
Free Radicals
Biochemical Phenomena
Safflower Oil
Unsaturated Dietary Fats
Soybean Oil
Fish Oils
Lipid Peroxides
Dietary Fats
Liver
Brain
Inbred SHR Rats
Lipid Peroxidation
Skeletal Muscle
Fatty Acids

Keywords

  • Fish oil
  • Perilla oil
  • Peroxidizability
  • Protein carbonyl
  • Stroke-prone spontaneously hypertensive rat

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Protein carbonyl content roughly reflects the unsaturation of lipids in muscle but not in other tissues of stroke-prone spontaneously hypertensive strain (SHRSP) rats fed different fats and oils. / Sato, Akira; Huang, Min Zhao; Watanabe, Shiro; Okuyama, Harumi; Nakamoto, Hideko; Radak, Zsolt; Goto, Sataro.

In: Biological and Pharmaceutical Bulletin, Vol. 21, No. 12, 01.01.1998, p. 1271-1276.

Research output: Contribution to journalArticle

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