Protein-protein interactions in solution and their interplay with protein specific functions

Takaaki Sato, Toshiko Fukasawa, Togo Shimozawa, Teruyuki Komatsu, Hiromi Sakai, Shin'Ichi Ishiwata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We summarize recent developments of our small angle scattering studies on protein-protein interactions in solution. We have been focusing especially on representative proteins that function at exceptionally high concentration in human body, whose collective nature, rather than a specialized function of an isolated single molecule, plays an important role for their specific biological functions; for instance, human serum albumin (HSA), actin, and human hemoglobin (Hb). We use a static structure factor analysis, which offers information about spatial distributions of the proteins, as well as a Fourier inversion technique for the form factor, giving a real-space picture of the protein assemblies.

Original languageEnglish
Article numberSA002
JournalJournal of the Physical Society of Japan
Volume81
Issue numberSUPPL. A
Publication statusPublished - 2012 Sep
Externally publishedYes

Keywords

  • Protein solutions
  • Small angle X-ray scattering (SAXS)

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Sato, T., Fukasawa, T., Shimozawa, T., Komatsu, T., Sakai, H., & Ishiwata, SI. (2012). Protein-protein interactions in solution and their interplay with protein specific functions. Journal of the Physical Society of Japan, 81(SUPPL. A), [SA002].