Protein-protein interactions in solution and their interplay with protein specific functions

Takaaki Sato, Toshiko Fukasawa, Togo Shimozawa, Teruyuki Komatsu, Hiromi Sakai, Shin'Ichi Ishiwata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We summarize recent developments of our small angle scattering studies on protein-protein interactions in solution. We have been focusing especially on representative proteins that function at exceptionally high concentration in human body, whose collective nature, rather than a specialized function of an isolated single molecule, plays an important role for their specific biological functions; for instance, human serum albumin (HSA), actin, and human hemoglobin (Hb). We use a static structure factor analysis, which offers information about spatial distributions of the proteins, as well as a Fourier inversion technique for the form factor, giving a real-space picture of the protein assemblies.

Original languageEnglish
Article numberSA002
JournalJournal of the Physical Society of Japan
Volume81
Issue numberSUPPL. A
Publication statusPublished - 2012 Sep
Externally publishedYes

Fingerprint

proteins
interactions
factor analysis
hemoglobin
human body
albumins
serums
assemblies
form factors
spatial distribution
inversions
scattering
molecules

Keywords

  • Protein solutions
  • Small angle X-ray scattering (SAXS)

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Sato, T., Fukasawa, T., Shimozawa, T., Komatsu, T., Sakai, H., & Ishiwata, SI. (2012). Protein-protein interactions in solution and their interplay with protein specific functions. Journal of the Physical Society of Japan, 81(SUPPL. A), [SA002].

Protein-protein interactions in solution and their interplay with protein specific functions. / Sato, Takaaki; Fukasawa, Toshiko; Shimozawa, Togo; Komatsu, Teruyuki; Sakai, Hiromi; Ishiwata, Shin'Ichi.

In: Journal of the Physical Society of Japan, Vol. 81, No. SUPPL. A, SA002, 09.2012.

Research output: Contribution to journalArticle

Sato, T, Fukasawa, T, Shimozawa, T, Komatsu, T, Sakai, H & Ishiwata, SI 2012, 'Protein-protein interactions in solution and their interplay with protein specific functions', Journal of the Physical Society of Japan, vol. 81, no. SUPPL. A, SA002.
Sato T, Fukasawa T, Shimozawa T, Komatsu T, Sakai H, Ishiwata SI. Protein-protein interactions in solution and their interplay with protein specific functions. Journal of the Physical Society of Japan. 2012 Sep;81(SUPPL. A). SA002.
Sato, Takaaki ; Fukasawa, Toshiko ; Shimozawa, Togo ; Komatsu, Teruyuki ; Sakai, Hiromi ; Ishiwata, Shin'Ichi. / Protein-protein interactions in solution and their interplay with protein specific functions. In: Journal of the Physical Society of Japan. 2012 ; Vol. 81, No. SUPPL. A.
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