Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test

A study in healthy subjects

Akihiko Oshima, Hideichi Miyano, Saori Yamashita, Toshimi Owashi, Shinichi Suzuki, Yuji Sakano, Teruhiko Higuchi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The combined dexamethasone/CRH test (DEX/CRH test) is reported to produce augmented ACTH and cortisol responses in various psychiatric disorders as well as in some non-psychiatric conditions. To examine whether stress affects the outcome of DEX/CRH test, two stress groups in a repeated measures design were compared to an age-matched control group with regard to the psychological, autonomic and neuroendocrine responses after the combined dexamethasone and CRH challenge. Cold pressor (4°C, total 10 min) produced stronger subjective distress than mental arithmetic (15 min). Cold exposure, but not the mental test, elevated systolic and diastolic blood pressure, whereas the mental test increased pulse rate and skin conductance level more markedly than cold exposure. Neither stressor produced a significantly enhanced response of ACTH and cortisol in DEX/CRH test, and there was no correlation between psychological and neuroendocrine responses. These findings suggest that different stressors induce different patterns of sympathetic activation and that acute stress is unlikely to affect the results of DEX/CRH test.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalJournal of Psychiatric Research
Volume35
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Dexamethasone
Healthy Volunteers
Psychology
Intelligence Tests
Adrenocorticotropic Hormone
Hydrocortisone
Blood Pressure
Exercise Test
Psychiatry
Research Design
Heart Rate
Control Groups
Skin

Keywords

  • Cold pressor
  • Hypothalamic-pituitary-adrenal axis
  • Mental arithmetic
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test : A study in healthy subjects. / Oshima, Akihiko; Miyano, Hideichi; Yamashita, Saori; Owashi, Toshimi; Suzuki, Shinichi; Sakano, Yuji; Higuchi, Teruhiko.

In: Journal of Psychiatric Research, Vol. 35, No. 2, 2001, p. 95-104.

Research output: Contribution to journalArticle

Oshima, Akihiko ; Miyano, Hideichi ; Yamashita, Saori ; Owashi, Toshimi ; Suzuki, Shinichi ; Sakano, Yuji ; Higuchi, Teruhiko. / Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test : A study in healthy subjects. In: Journal of Psychiatric Research. 2001 ; Vol. 35, No. 2. pp. 95-104.
@article{74655a1df03c4b79a4a6b071ee9d8c13,
title = "Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test: A study in healthy subjects",
abstract = "The combined dexamethasone/CRH test (DEX/CRH test) is reported to produce augmented ACTH and cortisol responses in various psychiatric disorders as well as in some non-psychiatric conditions. To examine whether stress affects the outcome of DEX/CRH test, two stress groups in a repeated measures design were compared to an age-matched control group with regard to the psychological, autonomic and neuroendocrine responses after the combined dexamethasone and CRH challenge. Cold pressor (4°C, total 10 min) produced stronger subjective distress than mental arithmetic (15 min). Cold exposure, but not the mental test, elevated systolic and diastolic blood pressure, whereas the mental test increased pulse rate and skin conductance level more markedly than cold exposure. Neither stressor produced a significantly enhanced response of ACTH and cortisol in DEX/CRH test, and there was no correlation between psychological and neuroendocrine responses. These findings suggest that different stressors induce different patterns of sympathetic activation and that acute stress is unlikely to affect the results of DEX/CRH test.",
keywords = "Cold pressor, Hypothalamic-pituitary-adrenal axis, Mental arithmetic, Sympathetic nervous system",
author = "Akihiko Oshima and Hideichi Miyano and Saori Yamashita and Toshimi Owashi and Shinichi Suzuki and Yuji Sakano and Teruhiko Higuchi",
year = "2001",
doi = "10.1016/S0022-3956(01)00010-3",
language = "English",
volume = "35",
pages = "95--104",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test

T2 - A study in healthy subjects

AU - Oshima, Akihiko

AU - Miyano, Hideichi

AU - Yamashita, Saori

AU - Owashi, Toshimi

AU - Suzuki, Shinichi

AU - Sakano, Yuji

AU - Higuchi, Teruhiko

PY - 2001

Y1 - 2001

N2 - The combined dexamethasone/CRH test (DEX/CRH test) is reported to produce augmented ACTH and cortisol responses in various psychiatric disorders as well as in some non-psychiatric conditions. To examine whether stress affects the outcome of DEX/CRH test, two stress groups in a repeated measures design were compared to an age-matched control group with regard to the psychological, autonomic and neuroendocrine responses after the combined dexamethasone and CRH challenge. Cold pressor (4°C, total 10 min) produced stronger subjective distress than mental arithmetic (15 min). Cold exposure, but not the mental test, elevated systolic and diastolic blood pressure, whereas the mental test increased pulse rate and skin conductance level more markedly than cold exposure. Neither stressor produced a significantly enhanced response of ACTH and cortisol in DEX/CRH test, and there was no correlation between psychological and neuroendocrine responses. These findings suggest that different stressors induce different patterns of sympathetic activation and that acute stress is unlikely to affect the results of DEX/CRH test.

AB - The combined dexamethasone/CRH test (DEX/CRH test) is reported to produce augmented ACTH and cortisol responses in various psychiatric disorders as well as in some non-psychiatric conditions. To examine whether stress affects the outcome of DEX/CRH test, two stress groups in a repeated measures design were compared to an age-matched control group with regard to the psychological, autonomic and neuroendocrine responses after the combined dexamethasone and CRH challenge. Cold pressor (4°C, total 10 min) produced stronger subjective distress than mental arithmetic (15 min). Cold exposure, but not the mental test, elevated systolic and diastolic blood pressure, whereas the mental test increased pulse rate and skin conductance level more markedly than cold exposure. Neither stressor produced a significantly enhanced response of ACTH and cortisol in DEX/CRH test, and there was no correlation between psychological and neuroendocrine responses. These findings suggest that different stressors induce different patterns of sympathetic activation and that acute stress is unlikely to affect the results of DEX/CRH test.

KW - Cold pressor

KW - Hypothalamic-pituitary-adrenal axis

KW - Mental arithmetic

KW - Sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=0034983038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034983038&partnerID=8YFLogxK

U2 - 10.1016/S0022-3956(01)00010-3

DO - 10.1016/S0022-3956(01)00010-3

M3 - Article

VL - 35

SP - 95

EP - 104

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 2

ER -