Psychosocial factors influencing the short-term outcome of antithyroid drug therapy in Graves' disease

Kazuhiro Yoshiuchi, Hiroaki Kumano, Shinobu Nomura, Hiroshi Yoshimura, Kunihiko Ito, Yoshio Kanaji, Tomifusa Kuboki, Hiroyuki Suematsu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: Although psychological stress and smoking have-been proposed as factors contributing to Graves' disease, their independent roles in the course of this disease have not been determined. We assessed the association between the course of Graves' disease and psychosocial factors by using multivariate analysis. Methods: We investigated the association between the short-term outcome of Graves' disease (assessed 12 months after the beginning of antithyroid drug therapy) and stressful life events, daily hassles, smoking, drinking habits, coping skills, and social support (before and 6 months after beginning therapy) in 230 patients (182 women and 48 men) with newly diagnosed Graves' disease, using a logistic regression model. Results: After adjustment for smoking, coping skills, and thyroid function, daily hassles scores in women at 6 months after beginning therapy were significantly associated with a hyperthyroid state 12 months after beginning therapy. The relative risk was 3.9 for women with higher daily hassles scores compared with women with lower daily hassles scores (95% confidence interval, 1.1 to 13.2; p < .05). Smoking was not significantly associated with a hyperthyroid state 12 months after beginning therapy in either women or men. Conclusions: Chronic psychological stress is associated with the course of Graves' disease in women.

Original languageEnglish
Pages (from-to)592-596
Number of pages5
JournalPsychosomatic Medicine
Volume60
Issue number5
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Chronic psychological stress
  • Graves' disease
  • Multivariate analysis
  • Odds ratio
  • Smoking

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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