Pulmonary effects of sodium fluoride aerosol on rats

X. Q. Chen, K. Machida, K. Isizaki, N. Nisio, M. Ando

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Five-week-old male Fischer rats were exposed 3 hr per day for either 5 or 10 days to three concentrations of sodium fluoride aerosol (1.11, 3.33, and 10.3 mg F/m3). A significant increase in lung weight was observed at the highest concentration. The activity of lactate dehydrogenase (LDH) and total protein concentration in bronchoalveolar lavage (BAL) fluid were also significantly higher in rats exposed to 3.33 and 10.3 mg F/m3. Neutrophil phagocytic activity in the blood was stimulated by 10-day exposure, and a significant increase in bactericidal activity and superoxide production was observed by exposure to 3.33 mg F/m3 but not to 10.3 mg F/m3.

    Original languageEnglish
    Pages (from-to)159-167
    Number of pages9
    JournalFluoride
    Volume33
    Issue number4
    Publication statusPublished - 2000

    Fingerprint

    sodium fluoride
    Sodium Fluoride
    Inbred F344 Rats
    Bronchoalveolar Lavage Fluid
    aerosols
    Aerosols
    L-Lactate Dehydrogenase
    Superoxides
    Rats
    Neutrophils
    lungs
    Weights and Measures
    Lung
    rats
    phagocytosis
    lactate dehydrogenase
    superoxide anion
    neutrophils
    Proteins
    Blood

    Keywords

    • Aerosol fluoride
    • Airborne fluoride
    • Bronchoalveolar lavage
    • Lactate dehydrogenase
    • Neutrophil stimulation
    • Phagocytic activity
    • Pulmonary effects
    • Rat lungs

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)
    • Health, Toxicology and Mutagenesis
    • Public Health, Environmental and Occupational Health
    • Toxicology

    Cite this

    Chen, X. Q., Machida, K., Isizaki, K., Nisio, N., & Ando, M. (2000). Pulmonary effects of sodium fluoride aerosol on rats. Fluoride, 33(4), 159-167.

    Pulmonary effects of sodium fluoride aerosol on rats. / Chen, X. Q.; Machida, K.; Isizaki, K.; Nisio, N.; Ando, M.

    In: Fluoride, Vol. 33, No. 4, 2000, p. 159-167.

    Research output: Contribution to journalArticle

    Chen, XQ, Machida, K, Isizaki, K, Nisio, N & Ando, M 2000, 'Pulmonary effects of sodium fluoride aerosol on rats', Fluoride, vol. 33, no. 4, pp. 159-167.
    Chen XQ, Machida K, Isizaki K, Nisio N, Ando M. Pulmonary effects of sodium fluoride aerosol on rats. Fluoride. 2000;33(4):159-167.
    Chen, X. Q. ; Machida, K. ; Isizaki, K. ; Nisio, N. ; Ando, M. / Pulmonary effects of sodium fluoride aerosol on rats. In: Fluoride. 2000 ; Vol. 33, No. 4. pp. 159-167.
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