Pursuing the flow of information: Connectivity between bilateral premotor cortices predicts better accuracy in the phonological working memory task

Yumie Ono, Tatsuya Nanjo, Atsushi Ishiyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Using Magnetoencephalography (MEG) we studied functional connectivity of cortical areas during phonological working memory task. Six subjects participated in the experiment and their neuronal activity was measured by a 306-channel MEG system. We used a modified version of the visual Sternberg paradigm, which required subjects to memorize 8 alphabet letters in 2s for a late recall period. We estimated functional connectivity of oscillatory regional brain activities during the encoding session for each trial of each subject using beamformer source reconstruction and Granger causality analysis. Regional brain activities were mostly found in the bilateral premotor cortex (Brodmann area (BA) 6: PMC), the right dorsolateral prefrontal cortex (BA 9: DLPFC), and the right frontal eye field (BA 8). Considering that the left and right PMCs participate in the functions of phonological loop (PL) and the visuospatial sketchpad (VS) in the Baddeley's model of working memory, respectively, our result suggests that subjects utilized either single function or both functions of working memory circuitry to execute the task. Interestingly, the accuracy of the task was significantly higher in the trials where the alpha band oscillatory activities in the bilateral PMCs established functional connectivity compared to those where the PMC was not working in conjunction with its counterpart. Similar relationship was found in the theta band oscillatory activities between the right PMC and the right DLPFC, however in this case the establishment of functional connectivity significantly decreased the accuracy of the task. These results suggest that sharing the memory load with both PL- and VS- type memory storage circuitries contributed to better performance in the highly-demanding cognitive task.

Original languageEnglish
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages7404-7407
Number of pages4
DOIs
Publication statusPublished - 2013 Oct 31
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: 2013 Jul 32013 Jul 7

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period13/7/313/7/7

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Ono, Y., Nanjo, T., & Ishiyama, A. (2013). Pursuing the flow of information: Connectivity between bilateral premotor cortices predicts better accuracy in the phonological working memory task. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 7404-7407). [6611269] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6611269