Putting the brakes on reproduction: Implications for conservation, global climate change and biomedicine

John C. Wingfield, Nicole Perfito, Rebecca Calisi, George Bentley, T. Ubuka, M. Mukai, Sara O'Brien, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Seasonal breeding is widespread in vertebrates and involves sequential development of the gonads, onset of breeding activities (e.g. cycling in females) and then termination resulting in regression of the reproductive system. Whereas males generally show complete spermatogenesis prior to and after onset of breeding, females of many vertebrate species show only partial ovarian development and may delay onset of cycling (e.g. estrous), yolk deposition or germinal vesicle breakdown until conditions conducive for ovulation and onset of breeding are favorable. Regulation of this "brake" on the onset of breeding remains relatively unknown, but could have profound implications for conservation efforts and for "mismatches" of breeding in relation to global climate change. Using avian models it is proposed that a brain peptide, gonadotropin-inhibitory hormone (GnIH), may be the brake to prevent onset of breeding in females. Evidence to date suggests that although GnIH may be involved in the regulation of gonadal development and regression, it plays more regulatory roles in the process of final ovarian development leading to ovulation, transitions from sexual to parental behavior and suppression of reproductive function by environmental stress. Accumulating experimental evidence strongly suggests that GnIH inhibits actions of gonadotropin-releasing hormones on behavior (central effects), gonadotropin secretion (central and hypophysiotropic effects), and has direct actions in the gonad to inhibit steroidogenesis. Thus, actual onset of breeding activities leading to ovulation may involve environmental cues releasing an inhibition (brake) on the hypothalamo-pituitary-gonad axis.

    Original languageEnglish
    Pages (from-to)16-26
    Number of pages11
    JournalGeneral and Comparative Endocrinology
    Volume227
    DOIs
    Publication statusPublished - 2016 Feb 1

    Fingerprint

    Climate Change
    Breeding
    Reproduction
    climate change
    breeding
    gonadotropins
    Gonadotropins
    Gonads
    Ovulation
    ovulation
    gonads
    ovarian development
    hormones
    Hormones
    Vertebrates
    vertebrates
    Reproductive Behavior
    parental behavior
    germinal vesicle
    steroidogenesis

    Keywords

    • Birds
    • Environmental signals
    • Gonadotropin-inhibitory hormone
    • Gonadotropin-releasing hormone
    • Gonadotropins
    • Reproduction

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Putting the brakes on reproduction : Implications for conservation, global climate change and biomedicine. / Wingfield, John C.; Perfito, Nicole; Calisi, Rebecca; Bentley, George; Ubuka, T.; Mukai, M.; O'Brien, Sara; Tsutsui, Kazuyoshi.

    In: General and Comparative Endocrinology, Vol. 227, 01.02.2016, p. 16-26.

    Research output: Contribution to journalArticle

    Wingfield, John C. ; Perfito, Nicole ; Calisi, Rebecca ; Bentley, George ; Ubuka, T. ; Mukai, M. ; O'Brien, Sara ; Tsutsui, Kazuyoshi. / Putting the brakes on reproduction : Implications for conservation, global climate change and biomedicine. In: General and Comparative Endocrinology. 2016 ; Vol. 227. pp. 16-26.
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