Pyrizomicin A and B: Structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216

Toru Kimura, Yuki Inahashi, Hirotaka Matsuo, Takuya Suga, Masato Iwatsuki, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Takuji Nakashima

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

Original languageEnglish
Pages (from-to)606-608
Number of pages3
JournalJournal of Antibiotics
Volume71
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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