QCM sensing of a chemical nerve agent analog via electropolymerized molecularly imprinted polythiophene films

Aileen V. Vergara; Roderick B. Pernites; Shemaiah Pascua; Christina A. Binag; Rigoberto C. Advincula

doi:10.1002/pola.25077

QCM sensing of a chemical nerve agent analog via electropolymerized molecularly imprinted polythiophene films

Aileen V. Vergara, Roderick B. Pernites, Shemaiah Pascua, Christina A. Binag, Rigoberto C. Advincula^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The highly selective and sensitive detection of a chemical nerve agent analog pinacolyl methylphosphonate (PMP) was demonstrated using an electrochemically molecularly imprinted polymer (MIP) polythiophene film onto a quartz crystal microbalance (QCM) transducer surface. The fabrication and optimization of the sensor film was monitored by in situ electrochemistry-QCM (EC-QCM) measurements, which determined the change in mass and simultaneous change in redox properties of the polymer film. The film deposition, template loading, and template removal were evidenced by a combination of surface characterization techniques such as the attenuated total reflection infrared spectroscopy and high-resolution X-ray photoelectron spectroscopy. The fabricated MIP film demonstrated a limit of detection and a limit of quantification of ∼60 and ∼197 μM, respectively. The linear sensing range is between 125 and 250 μM concentration of PMP. Finally, theoretical modeling (AM1 semiempirical quantum calculations) studies revealed that a stable prepolymerization complex is formed in solution with the existence of H-bonding interactions using the 2:1 monomer-to-template ratio.

Original language	English
Pages (from-to)	675-685
Number of pages	11
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	50
Issue number	4
DOIs	https://doi.org/10.1002/pola.25077
Publication status	Published - 2012 Feb 15
Externally published	Yes

Keywords

electropolymerization
molecular imprinting
nerve agent
quartz crystal microbalance

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/pola.25077

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title = "QCM sensing of a chemical nerve agent analog via electropolymerized molecularly imprinted polythiophene films",

abstract = "The highly selective and sensitive detection of a chemical nerve agent analog pinacolyl methylphosphonate (PMP) was demonstrated using an electrochemically molecularly imprinted polymer (MIP) polythiophene film onto a quartz crystal microbalance (QCM) transducer surface. The fabrication and optimization of the sensor film was monitored by in situ electrochemistry-QCM (EC-QCM) measurements, which determined the change in mass and simultaneous change in redox properties of the polymer film. The film deposition, template loading, and template removal were evidenced by a combination of surface characterization techniques such as the attenuated total reflection infrared spectroscopy and high-resolution X-ray photoelectron spectroscopy. The fabricated MIP film demonstrated a limit of detection and a limit of quantification of ∼60 and ∼197 μM, respectively. The linear sensing range is between 125 and 250 μM concentration of PMP. Finally, theoretical modeling (AM1 semiempirical quantum calculations) studies revealed that a stable prepolymerization complex is formed in solution with the existence of H-bonding interactions using the 2:1 monomer-to-template ratio.",

keywords = "electropolymerization, molecular imprinting, nerve agent, quartz crystal microbalance",

author = "Vergara, {Aileen V.} and Pernites, {Roderick B.} and Shemaiah Pascua and Binag, {Christina A.} and Advincula, {Rigoberto C.}",

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AU - Vergara, Aileen V.

AU - Pernites, Roderick B.

AU - Pascua, Shemaiah

AU - Binag, Christina A.

AU - Advincula, Rigoberto C.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - The highly selective and sensitive detection of a chemical nerve agent analog pinacolyl methylphosphonate (PMP) was demonstrated using an electrochemically molecularly imprinted polymer (MIP) polythiophene film onto a quartz crystal microbalance (QCM) transducer surface. The fabrication and optimization of the sensor film was monitored by in situ electrochemistry-QCM (EC-QCM) measurements, which determined the change in mass and simultaneous change in redox properties of the polymer film. The film deposition, template loading, and template removal were evidenced by a combination of surface characterization techniques such as the attenuated total reflection infrared spectroscopy and high-resolution X-ray photoelectron spectroscopy. The fabricated MIP film demonstrated a limit of detection and a limit of quantification of ∼60 and ∼197 μM, respectively. The linear sensing range is between 125 and 250 μM concentration of PMP. Finally, theoretical modeling (AM1 semiempirical quantum calculations) studies revealed that a stable prepolymerization complex is formed in solution with the existence of H-bonding interactions using the 2:1 monomer-to-template ratio.

AB - The highly selective and sensitive detection of a chemical nerve agent analog pinacolyl methylphosphonate (PMP) was demonstrated using an electrochemically molecularly imprinted polymer (MIP) polythiophene film onto a quartz crystal microbalance (QCM) transducer surface. The fabrication and optimization of the sensor film was monitored by in situ electrochemistry-QCM (EC-QCM) measurements, which determined the change in mass and simultaneous change in redox properties of the polymer film. The film deposition, template loading, and template removal were evidenced by a combination of surface characterization techniques such as the attenuated total reflection infrared spectroscopy and high-resolution X-ray photoelectron spectroscopy. The fabricated MIP film demonstrated a limit of detection and a limit of quantification of ∼60 and ∼197 μM, respectively. The linear sensing range is between 125 and 250 μM concentration of PMP. Finally, theoretical modeling (AM1 semiempirical quantum calculations) studies revealed that a stable prepolymerization complex is formed in solution with the existence of H-bonding interactions using the 2:1 monomer-to-template ratio.

KW - electropolymerization

KW - molecular imprinting

KW - nerve agent

KW - quartz crystal microbalance

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QCM sensing of a chemical nerve agent analog via electropolymerized molecularly imprinted polythiophene films

Abstract

Keywords

ASJC Scopus subject areas

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