Quantitative analysis with advanced compensated polarized light microscopy on wavelength dependence of linear birefringence of single crystals causing arthritis

Akifumi Takanabe, Masahito Tanaka, Atsuo Taniguchi, Hisashi Yamanaka, Toru Asahi

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    To improve our ability to identify single crystals causing arthritis, we have developed a practical measurement system of polarized light microscopy called advanced compensated polarized light microscopy (A-CPLM). The A-CPLM system is constructed by employing a conventional phase retardation plate, an optical fibre and a charge-coupled device spectrometer in a polarized light microscope. We applied the A-CPLM system to measure linear birefringence (LB) in the visible region, which is an optical anisotropic property, for tiny single crystals causing arthritis, i.e. monosodium urate monohydrate (MSUM) and calcium pyrophosphate dihydrate (CPPD). The A-CPLM system performance was evaluated by comparing the obtained experimental data using the A-CPLM system with (i) literature data for a standard sample, MgF2, and (ii) experimental data obtained using an established optical method, high-accuracy universal polarimeter, for the MSUM. The A-CPLM system was found to be applicable for measuring the LB spectra of the single crystals of MSUM and CPPD, which cause arthritis, in the visible regions. We quantitatively reveal the large difference in LB between MSUM and CPPD crystals. These results demonstrate the usefulness of the A-CPLM system for distinguishing the crystals causing arthritis.

    Original languageEnglish
    Article number285402
    JournalJournal of Physics D: Applied Physics
    Volume47
    Issue number28
    DOIs
    Publication statusPublished - 2014 Jul 16

    Fingerprint

    arthritis
    Light polarization
    Birefringence
    Calcium Pyrophosphate
    polarized light
    quantitative analysis
    Optical microscopy
    birefringence
    Single crystals
    microscopy
    Wavelength
    single crystals
    Chemical analysis
    wavelengths
    Uric Acid
    calcium
    Calcium
    Crystals
    Polarimeters
    polarimeters

    Keywords

    • crystal-induced arthritis
    • high-accuracy universal polarimeter
    • linear birefringence
    • polarized light microscopy

    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Electronic, Optical and Magnetic Materials
    • Acoustics and Ultrasonics
    • Surfaces, Coatings and Films

    Cite this

    Quantitative analysis with advanced compensated polarized light microscopy on wavelength dependence of linear birefringence of single crystals causing arthritis. / Takanabe, Akifumi; Tanaka, Masahito; Taniguchi, Atsuo; Yamanaka, Hisashi; Asahi, Toru.

    In: Journal of Physics D: Applied Physics, Vol. 47, No. 28, 285402, 16.07.2014.

    Research output: Contribution to journalArticle

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