Quantitative cytochemical differences between young and old patients with lung cancer

M. S. Huang, H. Kato, C. Konaka, K. Nishimiya, K. Yoneyama, Norihiko Kawate, H. Katsunuma, Y. Hayata

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In order to study differences in the tumor growth and frequency of metastases between younger and older patients with lung cancer, we investigated the nuclear DNA and nuclear protein according to age by means of cytophotometry after combined staining with Feulgen and Naphthol Yellow S. On the basis of Feulgen-Naphthol Yellow S staining method, 13 patients less than 40 years old and 16 patients older than 70 years were investigated. Our results showed no significant difference in nuclear DNA contents between young and old patients, but there were significantly higher nuclear protein contents (p<0.05) and nuclear protein to nuclear DNA (NP/DNA) ratios (p<0.001) in young patients than in old patients. This suggests that young patients may have higher tumor proliferation (high nuclear protein contents and NP/DNA ratios). The lower nuclear protein content and NP/DNA ratio of older cases is in keeping with the general phenomenon of slower tumor growth and less frequent metastases in such cases.

Original languageEnglish
Pages (from-to)864-869
Number of pages6
JournalChest
Volume88
Issue number6
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Lung Neoplasms
Nuclear Proteins
DNA
Staining and Labeling
Neoplasm Metastasis
Cytophotometry
Neoplasms
Growth

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Huang, M. S., Kato, H., Konaka, C., Nishimiya, K., Yoneyama, K., Kawate, N., ... Hayata, Y. (1985). Quantitative cytochemical differences between young and old patients with lung cancer. Chest, 88(6), 864-869.

Quantitative cytochemical differences between young and old patients with lung cancer. / Huang, M. S.; Kato, H.; Konaka, C.; Nishimiya, K.; Yoneyama, K.; Kawate, Norihiko; Katsunuma, H.; Hayata, Y.

In: Chest, Vol. 88, No. 6, 1985, p. 864-869.

Research output: Contribution to journalArticle

Huang, MS, Kato, H, Konaka, C, Nishimiya, K, Yoneyama, K, Kawate, N, Katsunuma, H & Hayata, Y 1985, 'Quantitative cytochemical differences between young and old patients with lung cancer', Chest, vol. 88, no. 6, pp. 864-869.
Huang MS, Kato H, Konaka C, Nishimiya K, Yoneyama K, Kawate N et al. Quantitative cytochemical differences between young and old patients with lung cancer. Chest. 1985;88(6):864-869.
Huang, M. S. ; Kato, H. ; Konaka, C. ; Nishimiya, K. ; Yoneyama, K. ; Kawate, Norihiko ; Katsunuma, H. ; Hayata, Y. / Quantitative cytochemical differences between young and old patients with lung cancer. In: Chest. 1985 ; Vol. 88, No. 6. pp. 864-869.
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AU - Kawate, Norihiko

AU - Katsunuma, H.

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