Abstract
Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.
| Original language | English |
|---|---|
| Pages (from-to) | 367-372 |
| Number of pages | 6 |
| Journal | In Vitro Cellular & Developmental Biology - Animal |
| Volume | 50 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Cadmium
- Cytotoxicity
- Heat shock protein (HSP)
- Nanomaterial
- Quantum dots (QDs)
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
- Medicine(all)
Cite this
Quantum dots induce heat shock-related cytotoxicity at intracellular environment. / Migita, Satoshi; Moquin, Alexandre; Fujishiro, Hitomi; Himeno, Seiichiro; Maysinger, Dusica; Winnik, Françoise M.; Taniguchi, Akiyoshi.
In: In Vitro Cellular & Developmental Biology - Animal, Vol. 50, No. 4, 2014, p. 367-372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantum dots induce heat shock-related cytotoxicity at intracellular environment
AU - Migita, Satoshi
AU - Moquin, Alexandre
AU - Fujishiro, Hitomi
AU - Himeno, Seiichiro
AU - Maysinger, Dusica
AU - Winnik, Françoise M.
AU - Taniguchi, Akiyoshi
PY - 2014
Y1 - 2014
N2 - Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.
AB - Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.
KW - Cadmium
KW - Cytotoxicity
KW - Heat shock protein (HSP)
KW - Nanomaterial
KW - Quantum dots (QDs)
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UR - http://www.scopus.com/inward/citedby.url?scp=84898444768&partnerID=8YFLogxK
U2 - 10.1007/s11626-013-9693-2
DO - 10.1007/s11626-013-9693-2
M3 - Article
C2 - 24092018
AN - SCOPUS:84898444768
VL - 50
SP - 367
EP - 372
JO - In Vitro Cellular and Developmental Biology - Animal
JF - In Vitro Cellular and Developmental Biology - Animal
SN - 1071-2690
IS - 4
ER -