Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Satoshi Migita; Alexandre Moquin; Hitomi Fujishiro; Seiichiro Himeno; Dusica Maysinger; Françoise M. Winnik; Akiyoshi Taniguchi

doi:10.1007/s11626-013-9693-2

Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Satoshi Migita^*, Alexandre Moquin, Hitomi Fujishiro, Seiichiro Himeno, Dusica Maysinger, Françoise M. Winnik, Akiyoshi Taniguchi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.

Original language	English
Pages (from-to)	367-372
Number of pages	6
Journal	In Vitro Cellular and Developmental Biology - Animal
Volume	50
Issue number	4
DOIs	https://doi.org/10.1007/s11626-013-9693-2
Publication status	Published - 2014 Apr
Externally published	Yes

Keywords

Cadmium
Cytotoxicity
Heat shock protein (HSP)
Nanomaterial
Quantum dots (QDs)

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.1007/s11626-013-9693-2

Cite this

Quantum dots induce heat shock-related cytotoxicity at intracellular environment. / Migita, Satoshi; Moquin, Alexandre; Fujishiro, Hitomi; Himeno, Seiichiro; Maysinger, Dusica; Winnik, Françoise M.; Taniguchi, Akiyoshi.

In: In Vitro Cellular and Developmental Biology - Animal, Vol. 50, No. 4, 04.2014, p. 367-372.

Research output: Contribution to journal › Article › peer-review

@article{01aa2a4b37b74bbdb8caf7ead5f5f869,

title = "Quantum dots induce heat shock-related cytotoxicity at intracellular environment",

abstract = "Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.",

keywords = "Cadmium, Cytotoxicity, Heat shock protein (HSP), Nanomaterial, Quantum dots (QDs)",

author = "Satoshi Migita and Alexandre Moquin and Hitomi Fujishiro and Seiichiro Himeno and Dusica Maysinger and Winnik, {Fran{\c c}oise M.} and Akiyoshi Taniguchi",

year = "2014",

month = apr,

doi = "10.1007/s11626-013-9693-2",

language = "English",

volume = "50",

pages = "367--372",

journal = "In Vitro",

issn = "0073-5655",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - Quantum dots induce heat shock-related cytotoxicity at intracellular environment

AU - Migita, Satoshi

AU - Moquin, Alexandre

AU - Fujishiro, Hitomi

AU - Himeno, Seiichiro

AU - Maysinger, Dusica

AU - Winnik, Françoise M.

AU - Taniguchi, Akiyoshi

PY - 2014/4

Y1 - 2014/4

N2 - Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.

AB - Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.

KW - Cadmium

KW - Cytotoxicity

KW - Heat shock protein (HSP)

KW - Nanomaterial

KW - Quantum dots (QDs)

UR - http://www.scopus.com/inward/record.url?scp=84898444768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898444768&partnerID=8YFLogxK

U2 - 10.1007/s11626-013-9693-2

DO - 10.1007/s11626-013-9693-2

M3 - Article

C2 - 24092018

AN - SCOPUS:84898444768

VL - 50

SP - 367

EP - 372

JO - In Vitro

JF - In Vitro

SN - 0073-5655

IS - 4

ER -

Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this