Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Satoshi Migita; Alexandre Moquin; Hitomi Fujishiro; Seiichiro Himeno; Dusica Maysinger; Françoise M. Winnik; Akiyoshi Taniguchi

doi:10.1007/s11626-013-9693-2

Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Satoshi Migita, Alexandre Moquin, Hitomi Fujishiro, Seiichiro Himeno, Dusica Maysinger, Françoise M. Winnik, Akiyoshi Taniguchi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.

Original language	English
Pages (from-to)	367-372
Number of pages	6
Journal	In Vitro Cellular and Developmental Biology - Animal
Volume	50
Issue number	4
DOIs	https://doi.org/10.1007/s11626-013-9693-2
Publication status	Published - 2014 Apr
Externally published	Yes

Keywords

Cadmium
Cytotoxicity
Heat shock protein (HSP)
Nanomaterial
Quantum dots (QDs)

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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Quantum dots induce heat shock-related cytotoxicity at intracellular environment. / Migita, Satoshi; Moquin, Alexandre; Fujishiro, Hitomi; Himeno, Seiichiro; Maysinger, Dusica; Winnik, Françoise M.; Taniguchi, Akiyoshi.

In: In Vitro Cellular and Developmental Biology - Animal, Vol. 50, No. 4, 04.2014, p. 367-372.

Research output: Contribution to journal › Article › peer-review

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AU - Winnik, Françoise M.

AU - Taniguchi, Akiyoshi

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