Quasi-in vivo heart electrocardiogram measurement of ST period using convolution of cell network extracellular field potential propagation in lined-up cardiomyocyte cell-network circuit

Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A model for the quasi-in vivo heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs). When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs) of the in vitro cell network include both the depolarization data and the propagation manner of beating in the heart.

Original languageEnglish
Article number070213
JournalJapanese Journal of Applied Physics
Volume50
Issue number7 PART 1
DOIs
Publication statusPublished - 2011 Jul
Externally publishedYes

Fingerprint

electrocardiography
potential fields
Electrocardiography
Convolution
convolution integrals
Microelectrodes
propagation
Networks (circuits)
cells
Bioelectric potentials
Depolarization
arrhythmia
profiles
depolarization

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

@article{951446fbfde4466bad1cb1ea6755d790,
title = "Quasi-in vivo heart electrocardiogram measurement of ST period using convolution of cell network extracellular field potential propagation in lined-up cardiomyocyte cell-network circuit",
abstract = "A model for the quasi-in vivo heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs). When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs) of the in vitro cell network include both the depolarization data and the propagation manner of beating in the heart.",
author = "Tomoyuki Kaneko and Fumimasa Nomura and Kenji Yasuda",
year = "2011",
month = "7",
doi = "10.1143/JJAP.50.070213",
language = "English",
volume = "50",
journal = "Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes",
issn = "0021-4922",
publisher = "Japan Society of Applied Physics",
number = "7 PART 1",

}

TY - JOUR

T1 - Quasi-in vivo heart electrocardiogram measurement of ST period using convolution of cell network extracellular field potential propagation in lined-up cardiomyocyte cell-network circuit

AU - Kaneko, Tomoyuki

AU - Nomura, Fumimasa

AU - Yasuda, Kenji

PY - 2011/7

Y1 - 2011/7

N2 - A model for the quasi-in vivo heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs). When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs) of the in vitro cell network include both the depolarization data and the propagation manner of beating in the heart.

AB - A model for the quasi-in vivo heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs). When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs) of the in vitro cell network include both the depolarization data and the propagation manner of beating in the heart.

UR - http://www.scopus.com/inward/record.url?scp=79960696093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960696093&partnerID=8YFLogxK

U2 - 10.1143/JJAP.50.070213

DO - 10.1143/JJAP.50.070213

M3 - Article

VL - 50

JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

SN - 0021-4922

IS - 7 PART 1

M1 - 070213

ER -