Quasi-in vivo heart electrocardiogram measurement of ST period using convolution of cell network extracellular field potential propagation in lined-up cardiomyocyte cell-network circuit

Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda

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Abstract

A model for the quasi-in vivo heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs). When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs) of the in vitro cell network include both the depolarization data and the propagation manner of beating in the heart.

Original languageEnglish
Article number070213
JournalJapanese journal of applied physics
Volume50
Issue number7 PART 1
DOIs
Publication statusPublished - 2011 Jul 1

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ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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