Radially oriented nanostrand electrodes to boost glucose sensing in mammalian blood

Naeem Akhtar, Sherif A. El-Safty, Mamdouh E. Abdelsalam, Mohamed A. Shenashen, Hiroshi Kawarada

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Architecture of nanoscale electrochemical sensors for ultra-trace detection of glucose in blood is important in real-life sampling and analysis. To broaden the application of electrochemical sensing of glucose, we fabricated, for the first time, a glucose sensor electrode based on radially oriented NiO nanostrands (NSTs) onto 3D porous Ni foam substrate for monitoring, as well as selective and sensitive sensing of glucose in mammalian blood. The simple, scalable one-pot fabrication of this NST-Ni sensor design enabled control of the pattern of radially oriented NSTs onto 3D porous Ni foam substrate. The radial orientation of NST-Ni electrode onto the interior of the 3D porous substrate with controlled crystal structure size and atomic arrangement along the axis of the strands, intrinsic surface defects, and superior surface properties, such as hydrophilicity, high surface energy, and high density led to highly exposed catalytic active sites. The hierarchical NST-Ni electrode was used to develop a sensitive and selective sensor over a wide range of glucose concentrations among actively competitive ions, chemical species and molecular agents, and multi-cyclic sensing assays. The NST-Ni electrode shows significant glucose sensing performance in terms of unimpeded diffusion pathways, a wide range of concentration detection, and lower limit of detection (0.186. μM) than NiO nanosheet (NS)-Ni foam electrode pattern, indicating the effectiveness of the shape-dependent structural architecture of NST-Ni electrode. In this study, the NST-Ni electrode is fabricated to develop a simple, selective method for detecting glucose in physiological fluids (e.g., mammalian blood).

    Original languageEnglish
    Pages (from-to)656-665
    Number of pages10
    JournalBiosensors and Bioelectronics
    Volume77
    DOIs
    Publication statusPublished - 2016 Mar 15

    Fingerprint

    Glucose
    Electrodes
    Blood
    Foams
    Catalytic Domain
    Substrates
    Glucose sensors
    Electrochemical sensors
    Surface Properties
    Nanosheets
    Surface defects
    Sensors
    Hydrophilicity
    Hydrophobic and Hydrophilic Interactions
    Interfacial energy
    Surface properties
    Blood Glucose
    Limit of Detection
    Assays
    Crystal structure

    Keywords

    • Electrodes
    • Glucose
    • Mammalian blood
    • Nanostrands
    • Sensing

    ASJC Scopus subject areas

    • Biophysics
    • Biomedical Engineering
    • Biotechnology
    • Electrochemistry

    Cite this

    Radially oriented nanostrand electrodes to boost glucose sensing in mammalian blood. / Akhtar, Naeem; El-Safty, Sherif A.; Abdelsalam, Mamdouh E.; Shenashen, Mohamed A.; Kawarada, Hiroshi.

    In: Biosensors and Bioelectronics, Vol. 77, 15.03.2016, p. 656-665.

    Research output: Contribution to journalArticle

    Akhtar, Naeem ; El-Safty, Sherif A. ; Abdelsalam, Mamdouh E. ; Shenashen, Mohamed A. ; Kawarada, Hiroshi. / Radially oriented nanostrand electrodes to boost glucose sensing in mammalian blood. In: Biosensors and Bioelectronics. 2016 ; Vol. 77. pp. 656-665.
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