Radiation-induced graft polymerization is the key to develop high- performance functional materials for protein purification

Kyoichi Saito, Satoshi Tsuneda, Min Kim, Noboru Kubota, Kazuyuki Sugita, Takanobu Sugo

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

We have described a preparation scheme for immobilizing polymer chains at a uniformly high density onto a microfiltration membrane. Highly efficient protein recovery was demonstrated by the results of the determination of breakthrough and elution curves. The three requirements of high rate, high capacity, and repeated use for the protein recovery were satisfied by ensuring the occurrence of convection, multilayer binding, and hydrophilization, respectively. In addition, easy scale-up to fabrication of a membrane module was verified on a small scale.

Original languageEnglish
Pages (from-to)517-525
Number of pages9
JournalRadiation Physics and Chemistry
Volume54
Issue number5
DOIs
Publication statusPublished - 1999 May

ASJC Scopus subject areas

  • Radiation

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