Reactive oxygen and nitrogen species regulate key metabolic, anabolic, and catabolic pathways in skeletal muscle

Roland Nemes, Erika Koltai, Albert W. Taylor, Katsuhiko Suzuki, Ferenc Gyori, Zsolt Radak

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Reactive oxygen and nitrogen species (RONS) are important cellular regulators of key physiological processes in skeletal muscle. In this review, we explain how RONS regulate muscle contraction and signaling, and why they are important for membrane remodeling, protein turnover, gene expression, and epigenetic adaptation. We discuss how RONS regulate carbohydrate uptake and metabolism of skeletal muscle, and how they indirectly regulate fat metabolism through silent mating type information regulation 2 homolog 3 (SIRT3). RONS are causative/associative signaling molecules, which cause sarcopenia or muscle hypertrophy. Regular exercise influences redox biology, metabolism, and anabolic/catabolic pathways in skeletal muscle in an intensity dependent manner.

Original languageEnglish
Article number85
JournalAntioxidants
Volume7
Issue number7
DOIs
Publication statusPublished - 2018 Jul 5

Keywords

  • Oxidative stress
  • Skeletal muscle adaptation
  • Training

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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