Reactive oxygen and nitrogen species regulate key metabolic, anabolic, and catabolic pathways in skeletal muscle

Roland Nemes, Erika Koltai, Albert W. Taylor, Katsuhiko Suzuki, Ferenc Gyori, Zsolt Radak

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Reactive oxygen and nitrogen species (RONS) are important cellular regulators of key physiological processes in skeletal muscle. In this review, we explain how RONS regulate muscle contraction and signaling, and why they are important for membrane remodeling, protein turnover, gene expression, and epigenetic adaptation. We discuss how RONS regulate carbohydrate uptake and metabolism of skeletal muscle, and how they indirectly regulate fat metabolism through silent mating type information regulation 2 homolog 3 (SIRT3). RONS are causative/associative signaling molecules, which cause sarcopenia or muscle hypertrophy. Regular exercise influences redox biology, metabolism, and anabolic/catabolic pathways in skeletal muscle in an intensity dependent manner.

Original languageEnglish
Article number85
JournalAntioxidants
Volume7
Issue number7
DOIs
Publication statusPublished - 2018 Jul 5

Fingerprint

Reactive Nitrogen Species
Muscle
Reactive Oxygen Species
Skeletal Muscle
Metabolism
Sirtuin 3
Physiological Phenomena
Sarcopenia
Carbohydrate Metabolism
Muscle Contraction
Epigenomics
Hypertrophy
Oxidation-Reduction
Membrane Proteins
Gene expression
Fats
Gene Expression
Muscles
Carbohydrates
Membranes

Keywords

  • Oxidative stress
  • Skeletal muscle adaptation
  • Training

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Reactive oxygen and nitrogen species regulate key metabolic, anabolic, and catabolic pathways in skeletal muscle. / Nemes, Roland; Koltai, Erika; Taylor, Albert W.; Suzuki, Katsuhiko; Gyori, Ferenc; Radak, Zsolt.

In: Antioxidants, Vol. 7, No. 7, 85, 05.07.2018.

Research output: Contribution to journalReview article

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AU - Radak, Zsolt

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