Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography

Yuki Kagawa, Yuji Haraguchi, Satoshi Tsuneda, Tatsuya Shimizu

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Recent progress in tissue engineering technology has enabled us to develop thick tissue constructs that can then be transplanted in regenerative therapies. In clinical situations, it is vital that the engineered tissues to be implanted are safe and functional before use. However, there is currently a limited number of studies on real-time quality evaluation of thick living tissue constructs. Here we developed a system for quantifying the internal activities of engineered tissues, from which we can evaluate its quality in real-time.

    Original languageEnglish
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    DOIs
    Publication statusAccepted/In press - 2016

    Fingerprint

    Microelectrodes
    Optical tomography
    Tissue
    Oxygen
    Engineering technology
    Tissue engineering

    Keywords

    • Cell sheet
    • Oxygen consumption
    • Oxygen gradient
    • Real-time monitoring
    • Tissue engineering

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Biomaterials

    Cite this

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    AU - Haraguchi, Yuji

    AU - Tsuneda, Satoshi

    AU - Shimizu, Tatsuya

    PY - 2016

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    KW - Oxygen gradient

    KW - Real-time monitoring

    KW - Tissue engineering

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