Realization, characterization and functionalization of lipidic wrapped carbon nanotubes

Gianni Ciofani, Yosuke Obata, Izumi Sato, Yosuke Okamura, Vittoria Raffa, Arianna Menciassi, Paolo Dario, Naoya Takeda, Shinji Takeoka

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Mass-produced carbon nanotubes (CNTs) are strongly aggregated and highly hydrophobic, and processes to make them water soluble are required for biological applications. Both covalent and non-covalent strategies are pursued for obtaining stable, highly concentrated CNT aqueous dispersions. Covalent functionalization has the great disadvantage of producing an irreversible chemical modification of nanotubes, thus alterating their mechanical, chemical and electric properties. On the other hand, non-covalent functionalization is often obtained by employing surfactants that sensibly affect cell viability. Moreover, derivatization with biological moieties is often impossible through non-covalent CNT dispersion. This paper proposes a non-covalent dispersion of multi-wall CNT based on a lipidic mixture that can guarantee high concentration and high stability as well as high cytocompatibility. Moreover, CNTs wrapped with a lipid membrane are realized to demonstrate that the proposed CNTs can be functionalised with a dodecapeptide that specifically recognizes activated platelets without chemical modification of the nanotube itself.

    Original languageEnglish
    Pages (from-to)477-484
    Number of pages8
    JournalJournal of Nanoparticle Research
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2009 Feb

    Fingerprint

    Functionalization
    Carbon Nanotubes
    Nanotubes
    Carbon nanotubes
    Carbon
    carbon nanotubes
    Chemical modification
    nanotubes
    Membrane Lipids
    Platelets
    platelets
    Dispersions
    viability
    Surface-Active Agents
    chemical properties
    Chemical properties
    lipids
    Surfactant
    Electric properties
    Surface active agents

    Keywords

    • Biocompatibility
    • Carbon nanotubes
    • Dodecapeptide
    • Functionalization
    • Lipid membrane
    • Non-covalent modification

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Condensed Matter Physics
    • Modelling and Simulation
    • Chemistry(all)
    • Materials Science(all)
    • Bioengineering

    Cite this

    Realization, characterization and functionalization of lipidic wrapped carbon nanotubes. / Ciofani, Gianni; Obata, Yosuke; Sato, Izumi; Okamura, Yosuke; Raffa, Vittoria; Menciassi, Arianna; Dario, Paolo; Takeda, Naoya; Takeoka, Shinji.

    In: Journal of Nanoparticle Research, Vol. 11, No. 2, 02.2009, p. 477-484.

    Research output: Contribution to journalArticle

    Ciofani, Gianni ; Obata, Yosuke ; Sato, Izumi ; Okamura, Yosuke ; Raffa, Vittoria ; Menciassi, Arianna ; Dario, Paolo ; Takeda, Naoya ; Takeoka, Shinji. / Realization, characterization and functionalization of lipidic wrapped carbon nanotubes. In: Journal of Nanoparticle Research. 2009 ; Vol. 11, No. 2. pp. 477-484.
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