Recent advances in cell micropatterning techniques for bioanalytical and biomedical sciences

Jun Nakanishi, Tohru Takarada, Kazuo Yamaguchi, Mizuo Maeda

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

Cell micropatterning is an important technique for a wide range of applications, such as tissue engineering, cell-based drug screening, and fundamental cell biology studies. This paper overviews cell patterning techniques based on chemically modified substrates with different degrees of cell adhesiveness. In particular, the focus is on dynamic substrates that change their cell adhesiveness in response to external stimuli, such as heat, voltage, and light. Such substrates allow researchers to achieve an in situ alteration of patterns of cell adhesiveness, which is useful for coculturing multiple cell types and analyzing dynamic cellular activities. As an example of dynamic substrates, we introduce a dynamic substrate based on a caged compound, where we accomplished a light-driven alteration of cell adhesiveness and the analysis of a single cell's motility. 2008

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalAnalytical Sciences
Volume24
Issue number1
DOIs
Publication statusPublished - 2008 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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