Recent advances in enantioselective [2 + 2 + 2] cycloaddition

Takanori Shibata, Kyoji Tsuchikama

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkyne-alkyne-alkene cyclization for the generation of a quaternary carbon including spirocyclic system.

Original languageEnglish
Pages (from-to)1317-1323
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number8
DOIs
Publication statusPublished - 2008 Apr 8

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Recent advances in enantioselective [2 + 2 + 2] cycloaddition'. Together they form a unique fingerprint.

  • Cite this