Recent advances in enantioselective [2 + 2 + 2] cycloaddition

Takanori Shibata*, Kyoji Tsuchikama

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

253 Citations (Scopus)


Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkyne-alkyne-alkene cyclization for the generation of a quaternary carbon including spirocyclic system.

Original languageEnglish
Pages (from-to)1317-1323
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number8
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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