Recent advances in enantioselective [2 + 2 + 2] cycloaddition

Takanori Shibata, Kyoji Tsuchikama

    Research output: Contribution to journalArticle

    224 Citations (Scopus)

    Abstract

    Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkyne-alkyne-alkene cyclization for the generation of a quaternary carbon including spirocyclic system.

    Original languageEnglish
    Pages (from-to)1317-1323
    Number of pages7
    JournalOrganic and Biomolecular Chemistry
    Volume6
    Issue number8
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Alkynes
    Cycloaddition
    Cycloaddition Reaction
    cycloaddition
    alkynes
    Alkenes
    alkenes
    Iridium
    Rhodium
    Chirality
    Charcoal
    Cyclization
    iridium
    rhodium
    musculoskeletal system
    chirality
    Skeleton
    Transition metals
    Carbon
    Metals

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Chemistry(all)

    Cite this

    Recent advances in enantioselective [2 + 2 + 2] cycloaddition. / Shibata, Takanori; Tsuchikama, Kyoji.

    In: Organic and Biomolecular Chemistry, Vol. 6, No. 8, 2008, p. 1317-1323.

    Research output: Contribution to journalArticle

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