Recent development of vinylogous Mukaiyama aldol reactions

    Research output: Contribution to journalReview article

    12 Citations (Scopus)

    Abstract

    The vinylogous Mukaiyama aldol reaction (VMAR) is a powerful tool of polyketide synthesis, which constructs a large size structure by simultaneous introduction of the stereogenic center(s) and the α,β-unsaturated carbonyl group. A variety of stereocontrolled VMARs have been developed and applied to natural product synthesis. This review is focused on recent development of the vinylogous Mukaiyama aldol reaction using s-trans silyl dienolates.

    Original languageEnglish
    Pages (from-to)77-88
    Number of pages12
    JournalTetrahedron Letters
    Volume59
    Issue number2
    DOIs
    Publication statusPublished - 2018 Jan 10

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    Polyketides
    Biological Products
    3-hydroxybutanal

    Keywords

    • Natural product synthesis
    • Polyketide
    • Silyl dienolate
    • Stereoselective synthesis
    • Vinylogous Mukaiyama aldol reaction

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

    Cite this

    Recent development of vinylogous Mukaiyama aldol reactions. / Hosokawa, Seijiro.

    In: Tetrahedron Letters, Vol. 59, No. 2, 10.01.2018, p. 77-88.

    Research output: Contribution to journalReview article

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    keywords = "Natural product synthesis, Polyketide, Silyl dienolate, Stereoselective synthesis, Vinylogous Mukaiyama aldol reaction",
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